Glycolysis

Question 1

What does glycolysis use and produce?

Answer 1

Uses ATP

produces ATP

Question 2

What are the 3 net produces of glycolysis?

Answer 2

• ATP

-pyruvate

• NADH

Question 3

Where does glycolysis take place?

Answer 3

In the cytoplasm

Question 4

What does glycolysis not require and does it yeild much energy?

Answer 4

Does not require O2

does not yeild much energy

Question 5

What are the 6 points required for glycolysis?

Answer 5

1) glucose
2)fructose1,6 bisphosphate
3) 2x glyceraldehyde 3 phosphate
4) 2x pyruvate

Question 6

How is glycolysis regulated ?

Answer 6

Control of glucose availability

Question 7

What is pyruvate?

Answer 7

The end product of glycolysis & a central intermediate

Question 8

Describe fate 1?

Answer 8

Liver makes glucose for other organs

Question 9

Describe fate 2?

Answer 9

Pyruvate- alanine

Use amino acids as fuels- get rid of NH3

Question 10

Outline what is involved in phase 4?

Answer 10

Pyruvate and aerobic respiration

Question 11

What is the kerbs cycle?

Answer 11

Central to metabolism and linked to glycolysis

Question 12

What commits carbons from glycolysis to fats or the kerbs cycle?

Answer 12

Acetylene CoA

Question 13

Where does pyruvate have to cross into first?

Answer 13

Mitochondria

Question 14

What’s involved in the Karen’s cycle?

Answer 14

Converts 2C acetyl CoA to 2CO2 generating reducing cofactors

Question 15

What’s involved in the TCA cycle?

Answer 15

Interconvert central intermediates a central hub of metabolism

Question 16

How is the TCA cycle done?

Answer 16

Acetyl CoA (2C) + oxalocaetate (4C) = citrate (6C)

Question 17

How is the TCA cycle regulated?

Answer 17

Oxidises 2Cs —> 2CO2
- creates energy
- interconvert metabolic intermediates

Question 18

Outline what Cofactor disease BeriBeri is?

Answer 18

Deficiency in vitamin B1

Precursor of coenzyme

Question 19

What are 4 symptoms of cofactor disease BeriBeri?

Answer 19

• limb pain
• muscle weakness
• skin sensation distorted
• heart enlarged/inadequate

Question 20

What is involved in oxidative phosphorylation?

Answer 20

• oxidation
  -reduction
  -NADH/FADH
  -mitochondria
  -electron transport chain

Question 21

What’s the oxidative equation?

Answer 21

NADH/FADH + O2 = H2O

Question 22

What is the final electron acceptor for oxidative phosphorylation?

Answer 22

O2

Question 23

What gradient does the oxidative phosphorylation contain?

Answer 23

H+ gradient

Question 24

How often does a mitochondrial respiratory disorder occur?

Answer 24

1 in 5000

Generally progressive and multi-systemic

Question 25

What organs do mitochondrial repair our diseases attack?

Answer 25

organs with high energy demands