Glycogen Flashcards
1
Q
Outline the flow of aqueous humor
A
- formed in capillary bed of ciliary body
- –> posterior chamber —>through angle formed by lens and iris diaphragm —>Anterior chamber —>absorped by canal of Schlemm
2
Q
What is the MOA of metoclopramide
A
- Antagonist at D2 receptor
- Serotonin agonist
- Increase contractility in GI tract
3
Q
What is the rate limiter in glycogenesis?
A
Glycogen synthase
4
Q
What linkages does glycogen synthase make
A
alpha-1,4 glycosidic
5
Q
What linkages does Branching enzyme make
A
alpha-1,6 glycosidic
6
Q
Describe McArdle Disease (type V)
A
- Glycogen phosphorylase deficiency
- Rhabdomyolysis
- Myoglobinuria
- Renal failure
- Normal life expectency
7
Q
Describe Von Gierke Disease (type I)
A
- Glucose-6-phosphatase deficiency
- muscles don’t have this anyway . . problem with liver, kidney, and enterocytes
- SEVERE FASTING HYPOGLYCEMIA
- Glycogen buildup in liver
- Hepatosplenomegaly
- Enlargement of kidneys
- Increase serum lactate
- Increase uric acid
- hypertriglyceridemia
8
Q
Treatment for Von Gierke Disease
A
- Feed frequently
- Give corn starch at night
9
Q
Describe Cori Disease (type III)
A
- Deficiency of Debranching enzyme
- Milder form of Von Gierke disease
- Milder hypoglycemia
- no elevation of lactate
- No elevation in uric acid
10
Q
Pompe Disease (type II) is a deficiency in what
A
-alpha-1,4-glucosidase in lysosomes
11
Q
What are the two forms of Pompe disease
A
- infantile
- Adult
12
Q
Describe infantile Pompe disease
A
- More severe
- Severe muscle weakness
- Cardiomegaly and heart failure
- Shortened life expectancy
13
Q
Describe adult form Pompe Disease
A
- Same enzyme activity but less than normal
- No cardiac involvement
- Gradual onset of skeletal muscle weakness
- Diaphragm weakness
- Respiratory failure
14
Q
Describe the role of Debranching enzyme
A
- breaks apart alpha-1,6-glycosidic linkages
- also takes 3 of last 4 glucoses before the branch point and puts them on the end (4-alpha-D-glucanotransferase activity)
