Gluconeogenesis

Question 1

Damage to which part of the basal ganglia produces hemiballismus

Answer 1

subthalamic nucleus

Question 2

Where does gluconeogenesis occur

Answer 2

• hepatocytes
• kidney
• Intestinal epithelium

Question 3

When does gluconeogenesis occur

Answer 3

• Low Blood Glucose

- The hepatocytes share glycogen stores and convert other molecules into pyruvate to make glucose

Question 4

What can enter the process of gluconeogenesis

Answer 4

• Anything that can be converted to pyruvate
• Odd chain Fatty acids
• TCA cycle molecules
• Amino acids

Question 5

What Enzymes are needed in Gluconeogenesis?

Answer 5

• Pyruvate carboxylase
• PEP carboxykinase
• Fructose-1,6-bisphosphatase
• Glucose-6-phosphatase

Question 6

Enzyme: Pyruvate —-> Oxaloacetate?

Answer 6

Pyruvate carboxylase

Question 7

What is a cofactor for pyruvate carboxylase to convert pyruvate to oxaloacetate?

Answer 7

biotin (B7)

Question 8

Enzyme: oxaloacetate –>phosphoenolpyruvate

Answer 8

PEP carboxykinase

Question 9

Enzyme: Fructose-1,6- bisphosphate —-> Fructose-6-phosphate

Answer 9

Fructose-1,6-bisphosphatase

Question 10

Enzyme: Glucose-6-phosphate —->Glucose

Answer 10

Glucose phosphatase

Question 11

What is the rate limiting enzyme in Gluconeogenesis

Answer 11

-Fructose-1,6, bisphosphatase

Question 12

What stimulates the conversion of pyruvate back to phosphoenolpyruvate (PEP)

Answer 12

Acetyl CoA

Question 13

What stimulates Fructose-1,6-bisphosphatase?

Answer 13

ATP

Question 14

What inhibits Fructose-1,6-bisphosphatase?

Answer 14

• AMP

- Fructose-2,6-bisphosphate