Glucorticosteroids questions Flashcards
Effects of oral glucocorticosteroid use (>1 month)
a. decreased blood glucose levels
a. False. Increased
Effects of oral glucocorticosteroid use (>1 month)
b.osteoporosis
b. True.
Effects of oral glucocorticosteroid use (>1 month)
c.anabolic effect on muscle
c. False. Catabolic
Effects of oral glucocorticosteroid use (>1 month)
d. increased susceptibility to infection
d. True. Suppresses the immune response
Effects of oral glucocorticosteroid use (>1 month)
e. oedema in the elderly
e. True. Cause sodium retention. Therefore, cause oedema
Glucocorticosteroids
a. excessive use causes the suppression of the hypothalamic-pituitary-adrenal axis
a. True
b oral glucocorticosteroids are contraindicated in the management of auto-immune disease
b. False. They are used to treat
c.stimulate lung maturation in premature neonates
c. True
d. prevents the formation of NSAID-associated gastric ulceration
d. False. Increase the likelihood
e. topically applied hydrocortisone does not cause thinning of the skin
e. False. All cause skin thinning
The effects of glucocorticosteroids include
a. anti-inflammatory
a. True
b. stimulates the T-cell response
b. False. inhibit the immune response
c. increases the response to vaccines
c. False. inhibits the immune response
d. decreases prostaglandin synthesis
d. True
e. stimulates wound healing
e. False
In the therapeutic use of glucocorticosteroids
a. oral prednisolone increases blood glucose levels
a. True
b. glucocorticosteroid receptors are located in the cell membrane
b. False. BINDS Cytoplasmic glucocorticoid receptor
c. repeated cortisone injections increase the risk of osteonecrosis
c. True
d. in the elderly, oral glucocoticosteroid use increases fluid retention
d. True. increases sodium retention. Therefore, increases fluid retention
e. the use of oral methylprednisolone for more than two weeks increases circulating levels of ACTH
e. False
Corticosteroids
a. prednisone inhibits COX-I and COX-II
a. True. Steroids inhbit the genes encoding lipocortin. Therefore, decrease synthesis. Lipocortin stimulates phospholipase A2. PA2 stimulates cyclooxygenase producing COX 1 and 2
b. phospholipase A2 is stimulated by lipocortin
b. True.
c. beclomethasone is given to asthmatic patients to reduce inflammation
c. True
d. cortisone will precipitate allergic reactions
d. False.
e. corticosteroids modify enzyme activity
e. True.
Adverse-effects of corticosteroids
a. corticosteroids have an anabolic effect on muscles and are used as muscle bulkers
a. False. Catabolic
b. long-term treatment with prednisone causes dysregulation of the HPA-axis
b. True. Should be weened off
c. hydrocortisone stimulates bone growth in children
c. False. Bone catabolism
d. glucose levels are elevated with corticosteroid treatment
d. True
e. a “moon face” and “buffalo hump” are characteristic of long-term prednisone treatment
e. True.
Glucocorticosteroids
a. prednisolone suppresses allergic reactions
a. True
b. oral betamethasone increases circulating levels of ACTH
b. False. Low cortisol stimulates ACTH production. Thus, induction of a GCS will decrease ACTH production
c. hydrocortisone is used to treat ddison’s disease
c. True
d. Inhaled beclomethasone decreases inflammation in the lung
d. True
e. decrease plasma glucose levels
e. False. Increase glucose output from the liver
In the clinical use of glucocorticosteroids the following is/are true
a. topically applied glucocorticosteroid cream causes thinning of the skin
a. True.
b. inhaled glucocorticosteroids increases the risk of oesophageal candidiasis
b. True,
c. prednisone stimulates osteoblast activity in bone
c. False, osteoclast activity
d. long term oral glucocorticosteroid use increases skeletal muscle strength
d. False, catabolism
e. dexamethasone-induced lipocortin inhibits the action of phosphlipase A2
e. True.
In the clinical use of glucocorticosteroids
a. dexamethasone causes suppression of the hypothalamic-pituitary–adrenal axis
a. True
b. oral glucocorticosteroids suppress inflammation in rheumatoid arthritis
b. True
c. hydrocortisone is contraindicated in the management of an acute adrenal crisis
c. False, managed with parenteral hydrocortisone
d. orally administered prednisolone decreases plasma glucose levels
d. False, increases
e. topically applied hydrocortisone causes thinning of the skin
e. True
Glucocorticosteroids
a. stimulate interleukin-2 synthesis
a. False. Inhibit by inhibiting phospholipase A2
b. oral hydrocortisone use has a catabolic effect on muscle
b. True
c. fluticasone inhibits the inflammatory response in the lungs
c. True
d. budesonide is used to treat oral candidiasis
d. False, oral candidiasis is an adverse effect
e. in the elderly, orally administered prednisolone increases the risk of hypertension
e. True
