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Pharm test 2 > Anti-fungals > Flashcards

Anti-fungals Flashcards

1
Q

Azole antifungals

a. inhibit fungal lanosterol 14-demethylase

A

a. True.

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2
Q

Azole antifungals

b. cause congenital skeletal malformations when used in the first trimester of pregnancy

A

b. True

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3
Q

Azole antifungals

c. fluconazole induces cytochrome P450 enzymes c.

A

c. False. Inhibits

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4
Q

Azole antifungals

d. itraconazole is hepatotoxic

A

d. True

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5
Q

e. fluconazole is effective against Aspergillus infections

A

e. False. Voriconazole

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6
Q

Topical antifungals

a. terbinafine increases fungal ergosterol synthesis

A

a. False

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7
Q

b. nystatin is used in the treatment of oral candidiasis in infants

A

b. True.

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8
Q

c. clotrimazole is used in the treatment of vulvovaginal candidiasis

A

c. True

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9
Q

d. terbinafine is used as first line therapy in the treatment of athletes foot

A

d. True

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10
Q

e. terbinafine is ineffective against Tinea corporis

A

e. False

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11
Q

Topical antifungals

a. terbinafine stimulates fungal squalene epoxidase activity

A

a. False. Inhibits

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12
Q

b. nystatin is absorbed through the GIT

A

b. True

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13
Q

c. clotrimazole is used in the treatment of Tinea corporis

A

c. True

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14
Q

d. clotrimazole is used in the treatment of cutaneous candidiasis

A

d. False

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15
Q

e. terbinafine is ineffective against Tinea pedis (athletes foot)

A

e. False.

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16
Q

Antifungals

a.fluconazole inhibits cytochrome P450 enzymes

17
Q

b. fluconazole inhibits fungal ergosterol synthesis

18
Q

c. itraconazole is safe to use in patients with advanced liver failure

A

c. False. Hepatotoxic

19
Q

d. fluconazole is effective against aspergilosis

A

d. False. Amphotericin B and Voriconazole

20
Q

e. fluconazole is preferred to amphotericin B for invasive candidiasis in the first trimester of pregnancy

21
Q

Match the MOA to drug
a. Polyene macrolide (nystatin and amphotericin B)

  1. Inhibits fungal P450 enzymes, inhibits ergosterol synth (cell membrane) by inhibiting 14 demethylase
  2. Binds to ergosterol forms pores in fungal cell membrane
  3. Inhibits ergosterol synth (cell membrane) by inhibiting squalene epoxidase
  4. Inhibits fungal cell wall synthesis by inhibiting D glucan
A

a. Polyene macrolide: Binds to ergosterol forms pores in fungal cell membrane

22
Q

b. Echinocandins (capsofungin)

  1. Inhibits fungal P450 enzymes, inhibits ergosterol synth (cell membrane) by inhibiting 14 demethylase
  2. Binds to ergosterol forms pores in fungal cell membrane
  3. Inhibits ergosterol synth (cell membrane) by inhibiting squalene epoxidase
  4. Inhibits fungal cell wall synthesis by inhibiting D glucan
A

b. Echinocandins: Inhibits fungal cell wall synthesis by inhibiting D glucan

23
Q

c. Allyl amine (terbinafine)

  1. Inhibits fungal P450 enzymes, inhibits ergosterol synth (cell membrane) by inhibiting 14 demethylase
  2. Binds to ergosterol forms pores in fungal cell membrane
  3. Inhibits ergosterol synth (cell membrane) by inhibiting squalene epoxidase
  4. Inhibits fungal cell wall synthesis by inhibiting D glucan
A

c. Allyl amine (terbinafine): Inhibits ergosterol synth (cell membrane) by inhibiting squalene epoxidase

24
Q

d. Azole

  1. Inhibits fungal P450 enzymes, inhibits ergosterol synth (cell membrane) by inhibiting 14 demethylase
  2. Binds to ergosterol forms pores in fungal cell membrane
  3. Inhibits ergosterol synth (cell membrane) by inhibiting squalene epoxidase
  4. Inhibits fungal cell wall synthesis by inhibiting D glucan
A

d. Azole: Inhibits fungal P450 enzymes, inhibits ergosterol synth (cell membrane) by inhibiting 14 demethylase

25
Q

In the treatment of fungal infections

a. IV amphotericin B is nephrotoxic

26
Q

b. IV fluconazole is contraindicated in systemic candidiasis

A

b. False, systemic candidiasis is the primary indication for fluconazole

27
Q

c. nystatin drops are contraindicated for use in babies

A

c. False. Safe in infants

28
Q

d. terbinafine is used to treat athletes foot

A

d. True (Lamisil)

29
Q

e. voriconazole is used to treat Aspergillus infections

A

e. True (amphotericin B or voriconazole)

Pharm test 2 (11 decks)

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