GLP-1 Flashcards
What does GLP-1 stand for?
Glucagon-like peptide-1
True or False: GLP-1 is an incretin hormone.
True
What is the primary function of GLP-1 in glucose metabolism?
To stimulate insulin secretion in response to meals.
Fill in the blank: GLP-1 is produced in the ________ intestine.
small
Which cells in the pancreas does GLP-1 act upon?
Beta cells
What effect does GLP-1 have on gastric emptying?
It slows gastric emptying.
Multiple Choice: Which of the following is a physiological effect of GLP-1?
A) Increases glucagon secretion
B) Decreases appetite
C) Increases blood glucose levels
D) None of the above
B) Decreases appetite
True or False: GLP-1 increases the production of insulin during fasting.
False
What is the half-life of GLP-1 in the bloodstream?
About 1-2 minutes
Fill in the blank: The degradation of GLP-1 is primarily mediated by ________.
Dipeptidyl peptidase-4 (DPP-4)
Short Answer: Name one therapeutic use of GLP-1 receptor agonists.
Treatment of type 2 diabetes
Multiple Choice: Which of the following drugs is a GLP-1 receptor agonist?
A) Metformin
B) Liraglutide
C) Glipizide
D) Insulin
B) Liraglutide
What role does GLP-1 play in appetite regulation?
It promotes satiety and reduces hunger.
True or False: GLP-1 can help in weight loss for obese individuals.
True
Fill in the blank: GLP-1 is secreted in response to ________ intake.
nutrient
Short Answer: What is one major side effect of GLP-1 receptor agonists?
Nausea
Multiple Choice: GLP-1 secretion is stimulated by which of the following?
A) High fat meals
B) High carbohydrate meals
C) Protein intake
D) Both B and C
D) Both B and C
What is the primary site of action for GLP-1 in the central nervous system?
Hypothalamus
True or False: GLP-1 has no effect on cardiovascular health.
False
Fill in the blank: GLP-1 enhances ________ secretion from the pancreas.
insulin
Short Answer: What is one potential benefit of GLP-1 beyond glucose control?
Cardiovascular protection
Multiple Choice: Which condition is GLP-1 most commonly associated with?
A) Type 1 diabetes
B) Type 2 diabetes
C) Hypertension
D) Hyperthyroidism
B) Type 2 diabetes
What type of molecule is GLP-1 classified as?
Peptide hormone
True or False: GLP-1 receptor agonists can be administered orally.
False
Fill in the blank: The main effect of GLP-1 on glucagon secretion is to ________ it.
suppress
Short Answer: What is the mechanism by which GLP-1 lowers blood glucose levels?
By enhancing insulin secretion and inhibiting glucagon release.
Multiple Choice: Which of the following is a common form of GLP-1 therapy?
A) Oral tablets
B) Subcutaneous injections
C) Intravenous infusion
D) Inhaled powder
B) Subcutaneous injections
