Dpp4 Flashcards
What does DPP-4 stand for?
Dipeptidyl Peptidase-4
True or False: DPP-4 inhibitors are used primarily to treat Type 1 diabetes.
False
Which class of diabetes medications do DPP-4 inhibitors belong to?
Incretin-based therapies
Fill in the blank: DPP-4 inhibitors increase levels of ________.
incretins
Name one common DPP-4 inhibitor medication.
Sitagliptin
What is the primary mechanism of action of DPP-4 inhibitors?
They prevent the breakdown of incretin hormones.
True or False: DPP-4 inhibitors can cause weight gain.
False
What is the primary effect of incretin hormones on blood sugar levels?
They lower blood sugar levels.
Multiple Choice: Which of the following is NOT a common side effect of DPP-4 inhibitors? A) Nausea B) Headache C) Weight gain D) Gastrointestinal discomfort
C) Weight gain
What is the recommended starting dose of Sitagliptin for adults?
100 mg once daily
Fill in the blank: DPP-4 inhibitors are often combined with ________ medications for better glucose control.
metformin
True or False: DPP-4 inhibitors require dose adjustment in patients with renal impairment.
True
What is the cardiovascular benefit associated with DPP-4 inhibitors?
They have a neutral effect on cardiovascular outcomes.
Name another DPP-4 inhibitor medication besides Sitagliptin.
Linagliptin
Multiple Choice: DPP-4 inhibitors are primarily used to treat which condition? A) Hypertension B) Type 2 diabetes C) Hyperlipidemia D) Asthma
B) Type 2 diabetes
What is the effect of DPP-4 inhibitors on HbA1c levels?
They typically lower HbA1c levels by 0.5% to 1%.
True or False: DPP-4 inhibitors are associated with an increased risk of pancreatitis.
True
Fill in the blank: The main route of elimination for DPP-4 inhibitors is through the ________.
kidneys
What is the role of incretin hormones in the body?
They stimulate insulin secretion and reduce glucagon secretion.
Multiple Choice: Which of the following DPP-4 inhibitors does NOT require renal dose adjustment? A) Saxagliptin B) Linagliptin C) Sitagliptin D) Alogliptin
B) Linagliptin
What is a potential adverse effect of DPP-4 inhibitors related to skin?
Skin reactions such as rash or urticaria
True or False: DPP-4 inhibitors can be used as monotherapy for Type 2 diabetes.
True
Which hormone is primarily responsible for stimulating insulin secretion in response to meals?
GLP-1 (Glucagon-like peptide-1)
Fill in the blank: DPP-4 inhibitors should be taken ________.
orally
What is the effect of DPP-4 inhibitors on gastric emptying?
They have a neutral effect on gastric emptying.
Name the enzyme that DPP-4 inhibitors inhibit.
Dipeptidyl peptidase-4
Multiple Choice: Which of the following is a contraindication for DPP-4 inhibitors? A) History of angioedema B) Type 1 diabetes C) Chronic pancreatitis D) All of the above
D) All of the above
What is the common suffix for most DPP-4 inhibitors?
gliptin
True or False: DPP-4 inhibitors are typically used as first-line therapy for Type 2 diabetes.
False
What should be monitored regularly in patients taking DPP-4 inhibitors?
Blood glucose levels
Fill in the blank: DPP-4 inhibitors have a low risk of ________ compared to other diabetes medications.
hypoglycemia
