Glomerulonephritis Flashcards
Nephritic syndrome signs (5)
Proteinuria (not to same extent as nephrotic) Haematuria Azetaemia Red cell casts Oliguria A Hypertension
Three mechanisms of nephritic syndrome
Large Immune complex deposition
Antibodies attaching to pre-existing antigens deposited in sub epithelium
Antibodies to GBM
Three types of primary nephrotic syndrome
Minimal change
Focal segmental glomerulonephritis
Membranous GM
Three types of secondary nephrotic/nephritic syndrome
Lupus nephritis
Diabetes Mellitus
Anti GBM Ab mediated GN
Pauci immune ANCA related GN eg. Wegener’s
Three primary nephritic causes
IgA / HS purpura
Post infective GN
Membranoproliferative?
Nasal Polyps with haemoptysis
Churg-Strauss Syndrome
Pulmonary nodules with haemoptysis
Wegener’s granulomatosis : Micropathic polyangiitis
Three secondary causes of nephrotic syndrome
Lupus SLE
Vasculitis: pauci immune- Weg,ANCA,
Anti GBM Disease (Good Pastures)
Minimal change GN
Oedematous children
No change on light microscopy, foot process podocyte effacement on electron microscopy
Cardinal triad of nephrotic syndrome
Hypoalbuminaemia
Hyperlipidaemia
Proteinuria
Steroid sensitive nephrotic syndrome
Minimal change GN
Black HIV male with nephrotic syndrome
FSGS GN
Focal segmental sclerosis - aka parts of glomerulus and not all glomerulus affected
GN associated with the following conditions:
Penicillamine
Hepatitis B
BCC (or solid cancers)
Membranous GN
Which GN has IgG granular staining and what other appearance?
Membranous GNs
Spikes on silver staining
Treat with ponticelli regime
First sign of diabetic Nephropathy, and how to detect?
Microalbuminuria
Undetectable by dipstick, picked up by urine m/c/s
