Gastro Flashcards
Four most common causes of LOWER GI haemorrhage
Haemorrhoids Angiodysplasia Diverticulosis Carcinoma (Other, IBD, polyp, ischaemic colitis)
Three most common causes of pancreatitis
Alcohol and gallstones 60-80% Idiopathic - remaining 15% (Post op, ERCP) Other causes are Metabolic (hyperTAG, hypercalcaemia) And Infectious ( mumps, vital hepatitis) Drug induced (sulfonamide, thiazides)
Most common causes of SBO
Adhesions
Hernias
Most common causes of LBO
Strictures (diverticulitis)
Colorectal carcinoma
Volvulus
Causes of liver toxic drugs - PAID MCV
Paracetamol
Amiodarone
Isoniazid (and other TB drugs)
Doxycycline and diclofenac - NSAID
Methotrexate
Chlorambucil
Valproate
Liver screen for liver failure
Bloods: LFT, Bloods (low pt), lactate
Liver synthesis: INR, albumin,
Liver clearance: bilirubin
Paracetamol concentration Hepatitis serology A1AT Copper studies Iron studies
Two hereditary colorectal cancer syndromes
Familial adenomatous polyposis FAP
And
Hereditary non polyposis colorectal cancer HNPCC or Lynch syndrome
What is the gene penetrance of FAP and HNPCC ( Lynch)
FAP: APC gene, autosomal dominant
HNPCC: mismatch repair gene - 6 in total, Amsterdam criteria (3 relatives within 2 generation, 1 with cancer before 50 yo)
How often should FAP and HNPCC individuals be screened?
FAP: From 15 every 2 years colonoscopy, from 25 every 2 years gastroscope for jejunal polyps
HNPCC: From 25 every 2 years
Four most common causes of upper GI haemorrhage
Peptic ulcer disease Varices Oesophagitis Mallory Weiss tears (Erosive gastritis, carcinoma, AV malformation)
What is Duke’s criteria?
A- polyp not in muscularis propria
B- polyp extended in muscularis propria
C- polyp extended through MP and lymph node
D - extra colonal metastasis
Man is Stabbed in 9ICS MAL. What organ?
Spleen
Direct inguinal hernia enters canal through whAt structure?
Posterior wall of inguinal canal
Indirect inguinal hernia enters canal through ?
Deep inguinal ring
Cells producing HCl? Also produce what?
Parietal cells
Also intrinsic factor