Autoantibodies

Question 1

Anti Ro, Anti La

Answer 1

Sjogren’s Syndrome

Question 2

Rheumatoid Factor (RhF)

Answer 2

100%: Sjogren’s syndrome, Felty’s syndrome
70% RA
Mixed connective tissue disease, SLE, Systemic sclerosis

Question 3

Anti CCP (anticyclic citrullinated peptide Ab)

Answer 3

Rheumatoid arthritis (96%)

Question 4

ANA (Anti nuclear antibody)

Answer 4

> 95% SLE
75% Autoimmune hepatitis
Sjogren’s, Systemic sclerosis, RA

Question 5

Anti-double stranded DNA (dsDNA)

Answer 5

SLE (60%)

Question 6

Anti phospholipid Ab
Anti cardiolipin
Anti topoisomerase

Answer 6

Anti-phospholipid syndrome

Question 7

Anti centromere Ab

Answer 7

Limited systemic sclerosis

CREST syndrome

Question 8

Anti Jo-1 and Anti Mi-2

Answer 8

Polymyositis and dermatomyositis

Question 9

Diffuse systemic sclerosis is associated with what Ab?

Answer 9

Anti-Scl-70

Question 10

Anti Smooth muscle antibody is associated with? (Rheumatological and GIT)

Answer 10

SLE -20-30%

Autoimmune hepatitis 70%
PBC 50%
Idiopathic cirrhosis

Question 11

Anti mitochondrial DNA is associated with what 3 GIT conditions?

Answer 11

Primary biliary cirrhosis >95%
Autoimmune hepatitis 30%
Idiopathic cirrhosis 25-30%

Question 12

Gastro parietal cell Ab : associated with ?

Answer 12

Pernicious anaemia : >90%
Atrophic gastritis 40%
Normal 10%

Question 13

Alpha- gliadin Ab
Anti tissue transglutaminase
Anti endomyseal Ab

Answer 13

Coeliac disease

Question 14

Three antibodies associated with coeliac disease :

Answer 14

Alpha- gliadin Ab
Anti tissue transglutaminase
Anti endomyseal Ab

Question 15

Thyroid peroxidase Ab associated with

Answer 15

Hashimoto’s thyroiditis 88%
Grave’s>50%

Other thyroid conditions:
Islet cell Ab and glutamic acid decarboxylase Ab : DMT1

Question 16

Goodpasture’s disease is associated with

Answer 16

Glomerular basement membrane Ab

Question 17

Cytoplasmic Antineutrophil cytoplasmic Ab (C-ANCA) is associated with what three conditions?

Answer 17

Granulomatosis with polyangiitis (Wegener's) 90%
Microscopic polyangiitis (30%)
Polyarteritis nodosa (10%)

Question 18

Peri nuclear Antineutrophil cytoplasmic Ab (p-ANCA) is associated with what three conditions?

Answer 18

Churg - Strauss 
Pulmonary vasculatides (Goodpasture's)
Microscopic polyangiitis (45%)

Can also be +ve in PSC, UC Crohn’s, autoimmune hepatitis, RA, SLE

Question 19

ACh receptor Ab

Answer 19

Myasthenia gravis

Question 20

Anti voltage gated Ca channel Ab:

Answer 20

Lambert-Eaton syndrome

Anti voltage gated K channel Ab: limbic encephalopathy

Question 21

Anti Sm

Answer 21

Specific for lupus

Question 22

Anti TIF -1 Gamma Ab

Answer 22

High suspicion of Malignancy in dermatomyositis if this Ab present