Glomerular Dz Flashcards
Where is proteinuria first detected?
On a urine dipstick- semi-quantitative screening test that is more sensitive to albumin
How can you tell the difference of renal proteinuria caused by glomerular pathology and tubular pathology?
Glomerular pathology will cause a higher UPC ratio because it is allowing every protein to pass through
If the UPC is >8 what should be considered?
amyloidosis
What would the UPC ratio be if tubular disease was present?
UPC <2
what is the most significant proteinuria?
Glomerular protein loss- protein losing nephropathy
Which breeds are predisposed to glomerulonephritis?
Samoyed, cocker spaniel, sharpei and abyssinian
What is the average amount of BP readings you should obtain?
5
Why is hypercoagulability seen with glomerular dz?
Excessive loss of antithrombin leading to thromboemboli formation
How is hypercoagulability measured?
Thromboelastography
What is late glomerular disease characterized by?
Nephrotic syndrome- edema and loss of protein into urine from increased glomerular permeability
What is VERY LATE glomerular disease characterized by?
Uremic syndrome
Why is kidney biopsy contraindicated in IRIS stage IV?
results will come back and patient wouldn’t have made it that long or the patient could bleed out from coagulopathy
Where are the two international renal pathology service centers where biopsies are sent to?
Texas A&M and Ohio
What are findings seen with nephrotic syndrome?
Proteinuria, hypoalbuminemia, ascites/edema, hypercholesterolemia, hypertension, hypercoagulability
What is the drug of choice for glomerular disease?
Mycophenolate mofetil
What are physiologic causes of proteinuria?
Strenuous exercise, seizures, fever & stress
What are pre-renal causes of proteinuria?
Abnormal concentrations of proteins (multiple myeloma-bence jones proteins)
What breed is predisposed to x-linked glomerulonephritis?
Samoyed
What breed is predisposed to alport syndrome glomerulonephrits?
Cocker spaniels
What breeds are predisposed to amyloid deposits?
shar-pei, beagle, abyssinian, siamese
What is found when you use a thromboelastography on a hypercoagulable patient?
Decreased antithrombin, increased fibrin, increased d-dimers
what is the difference of early, late and very late glomerulonephritis?
Early: no CS, loss of BCS, lethargy, anorexia
Late: edema, loss of protein into urine, abdominal effusion, subcutaneous pitting edema, acute onset blindness, thromboembolic disease
Very late: uremic syndrome
What needs to be done before you put a patient on immunosuppressive therapy?
Origin of proteinuria from glomerulus
What does ACEi work on?
Decrease efferent glomerular arteriolar resistance
