Feline LUTD-Pandora Syndrome

Question 1

What is the major cause of Feline LUTD?

Answer 1

Idiopathic

Cats > 10 years= bacterial

Question 2

What is the gold standard dx test for feline interstitial cystitis?

Answer 2

Cystoscopy

Question 3

What is seen in terms of the mucosa and submucosa layer in a patient with feline idiopathic cystitis?

Answer 3

Mucosa: altered urinary glycosaminoglycan excretion
Submucosa: mast cell presence

Question 4

What is the inflammatory mediator in cats?

Answer 4

Substance P

Question 5

What part of the nervous system is responsible for storing vs. voiding urine?

Answer 5

Storing= SNS
Voiding= PSNS

Question 6

What nerves are associated with SNS, PSNS and external urethra sensation?

Answer 6

SNS: hypogastric n
PSNS: pelvic n
External urethral sensation: pudendal n.

Question 7

Release of NE does what to the bladder?

Answer 7

Allows bladder to fill

Relaxes smooth muscles in the bladder wall and excites the smooth muscles in the sphincter valve

Question 8

Release of ACh does what to the bladder?

Answer 8

Empties bladder

Release of ACh relaxes smooth muscles in sphincter valve and excites smooth muscles in wall of bladder

Question 9

What is the only thing that has been proven beneficial for feline LUTD therapy?

Answer 9

Environmental changes- reduce stress, litter box numbers, water sources, activity/playing