Glomerular Disease

Question 1

equivalent of clinical presentation of RPGN

Answer 1

crescentic glomerulonephritis

Question 2

producing 1-2g/hr of proteinuria, hematuria with rbc casts, pyuria, hypertension, fluid retention, increased serum creatinine over many weeks

Answer 2

acute nephritic syndrome

Question 3

onset of heavy proteinuria >3g/24hr, hypertension, hypercholesterolemia, hypoalbuminemia, edema/ anasarca, microsopic hematuria

Answer 3

nephrotic syndrome

Question 4

serum creatinine rises quickly over a span of days

Answer 4

Rapidly Progressive Glomerulonephritis (RPGN)

Question 5

subepithelial deposits on renal biopsy called “humps” is seen in

Answer 5

poststreptococcal glomerulonephritis

Question 6

grossly, the kidneys have subcapsular hemorrhages with a “flea-bitten” appearance

Answer 6

subacute bacterial endocarditis

Question 7

anit-GBM with lung hemorrhage and glomerulonephritis

Answer 7

goodpasture’s syndrome

Question 8

renal biopsy of goodpasture’s syndrome

Answer 8

focal or segmental necrosis

Question 9

most common form of glomerulonephritis

Answer 9

IgA nephropathy

Question 10

common presentation of IgA nephropahty

Answer 10

macroscopic hematuria (followed by URT infection)
proteinuria or asymptomatic microscopic hematuria

Question 11

similar with IgA nephropathy

Answer 11

henoch-schönlein purpura

Question 12

antibody more common in granulomatosis with polyangiitis

Answer 12

anti-proteinase 3 (PR3)

Question 13

antibody more common in microscopic polyangiitis or churg-strauss

Answer 13

anti-myeloperoxidase (MPO)

Question 14

more common in patients exposed to silica dust or with a1-antitrypsin deficiency

Answer 14

granulomatosis with polyangiitis

Question 15

peripheral eosinophilia, asthma, cutaneous purpura, mononeuritis and allergic rhinitis

Answer 15

churg-stauss syndrome

Question 16

thickening of the GBM

Answer 16

membranoproliferative glomerulonephritis (MPGN)

Question 17

MPGN type commonly associated with persistent hepatitis C

Answer 17

type I

Question 18

MPGN types II and III are driven by what complement pathway

Answer 18

alternative complement pathway

Question 19

the most proliferative MPGN type that shows mesangial interposition between the capillary basement membrane and endothelial cells producing a double contour called

Answer 19

tram tracking

Question 20

expansion of mesangium sometimes associated with mesangial hypercellularity

Answer 20

mesangioproliferative glomerulonephritis

Question 21

heavy proteinuria, minimal hematuria, hypoalbuminemia, hypercholesterolemia, edema and hypertension

Answer 21

nephrotic syndrome

Question 22

causes 70-90% of nephrotic syndrome in childhood but only 10-15% in adults

Answer 22

minimal change disease

Question 23

in electron microscopy it shows effacement of the foot processes with weakening of slit-pore membranes

Answer 23

minimal change disease

Question 24

pattern of segmental glomerular scars

Answer 24

focal segmantal glomerulosclerosis

Question 25

20% of cases of nephrotic syndrome

Answer 25

MGN or membranous nephropathy

Question 26

associated with malignancy

Answer 26

membranous glomerulonephritis

Question 27

MGN light microscopy

Answer 27

uniform thickening of BM membrane along peripheral capillary loops

Question 28

dense deposit disease

Answer 28

MPGN type II

Question 29

hematuria, thinning and splitting of the GBM, mild proteinuria

Answer 29

alport’s syndrome

Question 30

leading cause of ESRD

Answer 30

diabetic nephropathy

Question 31

in diabetic nephropathy, some develop eosinophilic, PAS + nodules called

Answer 31

nodular gloemrulosclerosis or Kimmelstiel-Wilson nodules

Question 32

most common hereditary nephritis

Answer 32

alport’s syndrome or hereditary nephritis