ALD & NAFLD

Question 1

most important risk factors involved in development of alcoholic liver disease

Answer 1

quantity and duration of alcohol intake

Question 2

3 major lesions of alcoholic liver disease

Answer 2

fatty liver
alcoholic hepatitis
cirrhosis

Question 3

one beer
4 oz of wine
1 oz od 80% spirits

Answer 3

~12g of alcohol

Question 4

consequence of HCV and alcohol

Answer 4

increased liver iron stores

porphyria cutanea tarda

Question 5

cornerstone in the treatment of alcoholic liver disease

Answer 5

complete abstinence from alcohol

Question 6

nonspecific TNF inhibitor

Answer 6

pentoxifylline

Question 7

excluded from transplant candidacy

Answer 7

patients with alcoholic hepatitis

Question 8

important comorbidity in the progression of alcoholic liver disease to cirrhosis in chronic drinkers

Answer 8

chronic infection with HCV

Question 9

most common histologic response to hepatotoxic stimuli

Answer 9

fatty liver

Question 10

most common chronic liver disease

Answer 10

NAFLD

Question 11

NAFLD is associated with

Answer 11

overweight/ obesity

insulin resistance

Question 12

net result of hyperinsulinemia

Answer 12

steatosis

Question 13

morphologic manifestation of lipotoxicity and resultant wound healing responses

Answer 13

NASH

Question 14

10g of ethanol equivalent to

Answer 14

one can of beer
4 oz of wine
1.5 oz (one shot) of distilled spirits

Question 15

gold standard for establishing severity of liver injury and fibrosis because it is both more sensitive and specific fro NAFLD

Answer 15

liver biopsy