GI Tract Flashcards
What is the life span of a chief cell?
about a year (long lifespan!)
Where is the primary site for absorption and digestion in the GI tract?
small intestine
Where would you find the parasympathetic motor nerve synapse in regards to the organ?
the ganglia are located very near the effector organ
Why is lipid digestion so drawn out?
it stages the amount of lipid released into the blood at one time to prevent issues from mass amounts of fat being introduced into the bloodstream
The production and secretion of urease ___ gastric pH and ___ acid production.
increases; increases
What are the 5 different classes of gastric glands?
- mucus secreting cells
- acid secreting cells
- pepsin secreting cells
- enteroendocrine cells
- undifferentiated stem cells
Food undergoes mechanical breakdown via muscle activity and chemical breakdown via gastric secretions to form ___.
chyme
The ____ is a small, blind-ended sac that is distal to the ileocecal junction.
appendix
Where would you find undifferentiated stem cells in gastric glands?
in the neck of the gland
Which structure of the rectum contains longitudinal folds called anal columns?
anal canal
How do you distinguish villi from plica circulares in section?
villi - core of lamina propria
plica - core of submucosa
Are anal glands branched, straight, tubular glands?
YES - which secrete mucus
What are the 5 phases of food breakdown?
ingestion fragmentation digestion absorption elimination
The stomach completes ___ and initiates ___ during the first phases of digestion.
fragmentation; digestion
What are APUD cells?
“amine precursor uptake and decarboxylation” cells
____ stimulates the contraction of the gallbladder and the release of bile acids.
CCK
__ cells secrete GIP, or gastric inhibitory peptide.
K
____ are extracellular droplets for transport; ____ are intracellular droplets for transport.
Micelles; chylomicrons
Epithelium of the villi is supported by the connective tissue ____ and contains capillaries and lymphatics for absorption of nutrients.
lamina propria
Where would you find parasympathetic ganglia in the GI tract?
ganglia are located within the walls of the gut organ, within the submucosa and muscularis externa
How often are enterocytes replaced?
every 3-5 days
Peyer’s patches contain both __ and __ cells.
B; T
How can someone decrease their risk of colon cancer?
- increasing fiber in diet
- decreases colon cancer
- by reducing transit time
- and increasing GI motility
What are the pancreatic proteolytic enzymes secreted as?
inactive precursors (zymogens); so, trypsinogen and chymotrypsinogen to prevent autolysis
What is the more technical term for swallowing?
degluttination
___ and ___ promote the secretion of the exocrine pancreas.
Secretin; CCK
What is secreted by G cells?
gastrin
Where are actively dividing stem cells of the small intestine located at the base of?
crypts
What is the inner, third layer of muscle in the muscularis externa of the stomach?
inner oblique
APUD cells are sometimes referred to as ___ cells since they target cells in the local vicinity.
paracrine
What are M-cells responsible for in MALT tissues?
antigen sampling
uptake of macromolecules
____ helps to produce and maintain an optimal pH for the very sensitive enzymes present in the small intestine.
Bicarbonate
___ and ___ amylases hydrolyze starch to disaccharides (sucrose, lactose, maltose, and isomaltose).
Salivary; pancreatic
What is the exit of the GI tract?
anus
Both the fundus and corpus of the stomach are ____ and almost non-discernible histologically.
glandular
What do the mucus secreting cells cover?
luminal surface and upper third of pit
In which mucosal layer might you find large numbers of lymphocytes and plasma cells?
within the lamina propria of the gut mucosa
What is one of the most common problems associated with the stomach?
peptic/gastric ulcers
Enterocytes produce various ____ for absorption of carbohydrates and amino acids.
carrier proteins
A cells secrete ___, which raises blood sugar.
glucagon
What are interspersed among the enterocytes and secrete mucus?
goblet cells
Where are plica circulares especially prominent?
in the jejunum
What are the clusters of parasympathetic ganglia within the submucosa called?
Meissner’s plexus (submucosal plexus)
How would glucose, galactose, or fructose be absorbed in the small intestine?
through facilitated diffusion since these are all monosaccharides
What are the two primary types of actions performed by the muscularis externa?
segmentation and peristalsis
____ is secreted by S cells and inhibits gastric secretions and stimulates smooth muscle contractions.
Secretin
Where are surface mucus cells located?
at the surface of gastric glands
What is the result of ingestion accompanied by fragmentation of food?
a bolus
___ actions in the gut are local contractions only that mix food. They can occur both proximally and distally (both directions).
Segmentation
Is pancreatic lipase water soluble?
YES
What is the brush border coated with?
protective glycocalyx of disaccharides
What are the large numbers of commensal bacteria found in the large intestine called?
coliforms
What are the glands associated with the GI tract?
liver
pancreas
intestinal glands
What type of connective tissue does the submucosa contain? What is its role?
loose to dense connective tissue; supports mucosa and contains larger blood vessels, nerves, and lymphatics
____ project into the lumen of the small intestine and are dome-shaped.
Peyer’s patches
What is the outer layer of the gut, containing a loose connective tissue layer and major nerves, vessels, and adipose tissue?
adventitia (serosa)
Can stem cells of the villi migrate up to replace any type of cell like stomach undifferentiated stem cells?
YES
Why is the term “peptic ulcer” preferred over “gastric ulcer?”
because the majority of these ulcers actually occur in the very first part of the duodenum
What is the most common sign of polyps?
rectal bleeding
How often are mucus secreting cells renewed?
every 3-5 or 4-7 days
How long is the small intestine in humans?
4-6 meters long
What would you find in the duodenum that is not present in the large intestine?
Brunner’s glands
The smooth muscle of the gut is controlled by the ____ nervous system.
autonomic
Where are parietal cells most numerous?
in the middle third of the gastric gland
___ action propels food distally in one direction ONLY with rhythmic contractions.
Peristalsis
____ stimulation is excitatory to the gut; ____ stimulation is inhibitory to the gut.
Parasympathetic; sympathetic
What step is ESSENTIAL to maximize the actions of pancreatic lipase?
emulsification of fat
Are carbohydrates starches?
YES
Does absorption occur in the stomach?
NO - except for water, alcohol, and some drugs
What are the prominent longitudinal folds in the stomach called?
rugae
In the lower third of the esophagus, what type of muscle is the muscularis externa composed of?
smooth muscle only
What do goblet cells synthesize? What is its function?
mucinogen (»mucus); lubricates and protects the epithelium
What secreted product helps delay gastric emptying?
GIP (gastric inhibitory peptide)
The liver, pancreas, and intestinal glands are all ____ of the GI tract.
embryological outgrowths
Where is mucinogen stored in goblet cells?
in membrane bound granules
____ coagulates milk proteins.
Rennin
What do surface mucus cells secrete?
thick insoluble mucus and bicarbonate ions
Enteroendocrine cells are what kind of cell? What do they do?
APUD cells; amine precursor uptake and decarboxylation
What are the 3 layers of mucosa?
epithelium
lamina propria
muscularis mucosae
What is the mesothelium?
the lining of the adventitia (simple squamous epithelium)
What bacteria are peptic ulcers associated with in chronic infections of the stomach?
Helicobacter pylori
What make up the epithelium of the villi?
enterocytes
Are the digested components of proteins and carbohydrates handled similarly in transport by the body?
YES - both transported to portal vein
Is the appendix active in adults?
NO - only in children
Panrcreatic secretions are highly ___. Why?
alkaline; high pH is due to high levels of bicarbonate
How do mucus secreting cells look on H+E staining?
clear
What is one of the cardinal features of Celiac disease?
malabsorption
What inhibits the secretion of gastrin?
somatostatin
What cells would you find in the mucosal epithelium of the small intestine but not in the epithelium of the large intestine?
paneth cells
The ___ of the stomach is surrounded by the smooth muscle cardiac sphnicter (GES) and contains predominantly mucus-secreting glands.
cardia
___ act as emulsifying agents for digestion of lipids, forming micelles.
Bile acids
What are the 3 overall functions of GI mucosa?
protection (barrier)
secretion
absorption