GI System Flashcards
What is the mucosa layer of the GI made up of?
epithelium
lamina propria
muscularis mucosa
Properties of epithelium in GI?
continuous lining in GI tract
shed and replaced every 2-3 days
apical side faces GI lumen, basolateral side faces interstitium and vasculature
extent of vili and crypts depend on the section function of GI
What is the lamina propria?
Loose connective tissue made up of elastic and collagen fibres
contains sensory nerves, lymph vessels and secretory glands
What is the muscularis mucosa?
thin layer of smooth muscle that increases surface area by creating ridges and folds
What is the submucosa?
Thicker layer with similar composition to lamina propria
incorporates blood vessels and nerve bundles that form a submucosal plexus- it is an integral part of enteric nervous system
What is the Meissner Plexus?
Submucosal plexus
What is the muscularis externa made up of?
circular muscle
myenteric plexus
longitudinal muscle
What is the Auerbach plexus?
Myenteric plexus
Properties of muscularis externa
ENS coordinates contractions to mix and move contents between compartments, sphincters regulate this flow.
What makes up the serosa?
Outermost layer of connective tissue and squamous epithelial cells
What do sections of the GI tract have if they do not have a serosal layer?
They connect directly with adventitia
What divisions of the autonomic nervous system regulate the GI?
parasympathetic
sympathetic
enteric
Where is GI innervation from the parasympathetic nervous system derived from?
Vagus in the medulla oblongata
Pelvic splanchnic nerves in S2-S4
What stimulates the sensory and motor components of the parasympathetic NS?
stretch
pressure
temperature
osmolarity
What are the primary transmitters of the parasympathetic NS in the GI?
acetylcholine ACh
gastric-releasing peptide
substance P
What processes does the parasympathetic nervous system facilitate in GI system? *
digestion and absorption of nutrients
Where does the nerves of the sympathetic nervous system originate and synapse?
Originate: thoracic region T5-T12 lumbar region L1-L3 celiac ganglion Synapse: superior mesenteric ganglion inferior mesenteric ganglion
What innverates the upper GI region? (sympathetic NS)
Nerves that synapse in superior cervical ganglion
decreases GI secretions and motility
Organisation of ENS nerves?
myenteric and submucosal plexuses