GI Hormones Flashcards by John Micah Powers

Q

Gastrin - Secretion site

A

G cells in Stomach

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Q

Gastrin - Stimulated by

A

Protein

Distension

Vagus

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Q

Gastrin - Action

A

Stimulates gastric acid secretion

Trophic effect of Gastric Mucosa (hypertrophy)

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Q

CCK - Secretion site

A

I cells in Duodenum & Jejunum

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Q

CCK - Stimulated by

A

Protein

Fat

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Q

CCK - Action

A

Pancreatic enzyme & bicarb secretion

Gallbladder contraction, relax sphincter of Oddi

Decrease gastric emptying

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Q

Secretin - Secretion site

A

S cells of Duodenum

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Q

Secretin - Stimulated by

A

Acid - #1

Fat

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Q

Secretin - Action

A

Pancreatic & Biliary bicard secretion

Decrease gastric acid secretion

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Q

GIP - Secretion site

A

K Cells in Duodenum & Jejunum

Glucose-Dependent Insulinotropic Peptide

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Q

GIP - Stimulated by

A

Fat

Protein

Glucose - rare?

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Q

GIP - Action

A

Increase insulin secretion

Decrease gastric acid secretion

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Q

Motilin - Secretion site

A

Candidate Hormone - 22 a.a. peptide

Upper Duodenum

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Q

Motilin - Stimulated by

A

Candidate Hormone

Fasting state

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Q

Motilin - Action

A

Candidate Hormone

Stimulates myoelectric complex which induces vigorous GI peristalsis

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Q

Pancreatic Polypeptide - Secretion site

A

Candidate Hormone - 36 a.a. peptide

Pancreas

Q

Pancreatic Polypeptide - Stimulated by

A

Candidate Hormone

Cho?

Protein

Lipid ingestion

Q

Pancreatic Polypeptide - Action

A

Candidate Hormone

Decrease Pancreatic enzyme secretion

Decrease Pancreatic HCO3 secretion

Q

Enteroglucagon - Secretion site

A

Candidate Hormone

Intestinal cells

Q

Enteroglucagon - Stimulated by

A

Candidate Hormone

Fat

Hypoglycemia

Q

Enteroglucagon - Action

A

Candidate Hormone

^ Hepatic glycogenolysis & gluconeogenesis

Q

Glucagon-like Peptide I - Secretion site

A

Candidate Hormone

Intestinal L cells

Q

Glucagon-like Peptide I - Stimulated by

A

Candidate Hormone

Hypoglycemia

Q

Glucagon-like Peptide I - Action

A

Candidate Hormone

^ Insulin secretion from pancreatic B cells

Decrease Gastric emptying

Q

Somatostatin

A

Paracrine

D Cells

Stomach, Duodenum, Pancreas

Inhibits acid secretion

Q

Histamine

A

ECL cells

Stimulates acid secretion