gi Flashcards

win

1
Q

constipation

causes
tx

A

• Persistent, difficult, infrequent or seemingly incomplete defecation
• Causes: IBS, medications, endocrine disorders, psych disorders, MS, neuro
disorders, malignancy, hemorrhoids, stricture, ischemia, inflammatory

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2
Q

diarrhea

causes

A

Causes: can be acute or chronic
• Acute (< 2 weeks): infection, medications
• Chronic (>4 weeks): medications, toxins, malabsorption, hormones, cancer,
dysmotility disorders, eating disorders, bariatric surgery, cholecystectomy

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3
Q

ileus

definition
causes
dx
tx

A

• Functional obstruction, dysmotility prevents intestinal contents from
being propelled distally, not a mechanical blockage
• Causes: surgery, electrolyte abnormalities (low K, low mag, low Na),
medications, intestinal ischemia, GI bleed, sepsis,
hyperparathyroidism, LL pneumonias, Ogilvie’s Syndrome, collagen
vascular disease (SLE or scleroderma)
• S/S: abdominal pain, distention, emesis, obstipation
• Diagnostics: CBC, CMP, x-ray first

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4
Q

SBO

causes
S/S
DX
TX

A
Mechanical obstruction
• Causes: adhesions, malignancy,
hernia, inflammation,
intussception, volvulus
• S/S: same as ileus
• Exam: oliguric, hypotension,
tachycardic, fever, decreased
bowel sounds
• Diagnostics: same as ileus
• Treatment: supportive care, NGT,
IVF fluids, foley, admit to ICU,
resection if conservative efforts
unsuccessful

S/S: abdominal pain, distention, emesis, obstipation
• Diagnostics: CBC, CMP, x-ray first then CT scan

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5
Q

large bowel Obstruction

definition 
s/s 
exam
dx 
tx
A
Blockage in the large bowel
• Causes: malignancy, diverticulosis,
volvulus
• S/S: abdominal pain, n/v
• Exam: Abdominal swelling and pain
• Diagnostics: abdominal x-ray or CT scan
• Treatment: surgical emergency
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6
Q

gastroparesis

definition
causes
s/s

A

Delayed gastric emptying in the absence of mechanical obstruction,
due to vagus nerve damage, food is unable to move through the
digestive system appropriately
• Causes: diabetes, gastric surgery, medication
• S/S: n/v, delayed gastric emptying, signs of malabsorption

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7
Q

gastroparesis

exam
dx
tx

A

Upper GI Series – excludes mechanical obstruction, retention of
barium without obstruction is diagnostic
• Endoscopy – highly suggestive
• Gastric emptying study – solids more sensitive than liquids

• Treatment: Reglan, erythromycin, botox, surgery

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8
Q

appenndicitis

A

Inflammation of the appendix leading to infection
• Older adult at risk for perforation, pain > 48 hours
increases risk
• Etiology not completely understood
• Symptoms: RLQ pain, anorexia, constipation, diarrhea,
fever, nausea, vomiting, radiates to right flank or RUQ, pain
progressively worsens, urinary symptoms
• Exam: RLQ tenderness, rebound tenderness, rectal pain,
rigidity, psoas sign, obturator sign, Rovsing’s sign, palpable mass (less common)
• Diagnostics: CBC, UA, amylase, lipase, pregnancy test, CT
scan (but may not always show inflammation)
• Treatment: appendectomy

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9
Q

acute cholecystitis

definition
causes

s/s
dx
tx

A

Acute inflammation of the gallbladder
• Causes: obstructed gallstone
• Inflammatory response
• 1. mechanical inflammation – increased intraluminal pressure and distention resulting in ischemia
• 2. chemical inflammation – lysolecithin release
• 3. bacterial inflammation – E. coli, Klebsiella, Strep, Clostridium
• S/S: fever, chills, rigors, RUQ pain , n/v, palpable mass, rebound tenderness,
distention, hypoactive bowel sounds if ileus,
• Diagnostics: CBC, LFTs, US to identify gallstones, HIDA scan to confirm, H
and P (fever, leukocytosis, RUQ pain)
• Treatment: cholecystectomy, cholecystomy

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10
Q

cirrhosis /chronic liver disease

definiton
causes
exam
dx
tx
A

Liver fibrosis causes distortion decreasing hepatocellular mass
resulting in decreased function and blood flow
• Causes: alcoholism, hepatitis, congenital, nonalcoholic
steatohepatitis
• S/S: nonspecific symptoms, to RUQ pain, fever, nausea, vomiting,
diarrhea, anorexia, malaise, ascites, edema, UGI bleed, palmer
erythema
• Exam: hepatosplenomegaly
• Diagnostics: LFTs, CMP, liver biopsy (no ETOH x 6 months)
• Treatment: abstinence, supportive care, treat underlying cause

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11
Q

acute hepatic failure

A

• Rapid liver failure, usually with no history of liver disease
• Causes: acetaminophen overdose, medications, herbals, hepatitis,
toxins, autoimmune, vascular abnormalities, cancer, sepsis
• S/S: jaundice, RUQ pain, abd swelling, n/v, malaise, AMS, lethargy
• Complications: bleeding (not making clotting factors), cerebral
edema, infections, renal failure
• Treatment: stop cause, liver transplant

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12
Q

acute viral hepatitis

A
• Systemic infection
affecting the liver
• Causes: Hep A, Hep B,
Hep C, Hep D, or Hep E (All
RNA viruses except Hep B)
• Diagnostics: LFTs, CMP,
CBC, see next slide
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13
Q

Hep A/E

S/S

transmission is

A

vowel comes from the bowel

A va E no vax

S/S RUQ pain
NV anorexia
weight loss
fever, chills jaundice dark urine history of exposure

transmission is fecal oral

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14
Q

hep C transmission and vax

A

blood / Semen no vax

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15
Q

hepatitis all type tx and dx

A

rest, activity as tolerated, nutrition and hydration

dx is presence of specific antibody/antigen in the serum

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16
Q

hep B Vax and transmission

A

blood, semen, saliva, yes vax

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17
Q

hep D is what, vax ?

A

Hepatitis superinfection on top of HBV, transmission is blood.

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18
Q

hep testing first antibody to appear in response to atigen

A

Reminder: IgM is first antibody to appear in response to an antigen

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19
Q

acute hep b testing

A

• Acute hep B: + HBsAg, + IgM Anti-HBc

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20
Q

chronic hep B antigen

A

Chronic hep B: + HBsAg

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21
Q

Acute hep A on chronic hep B

A

Acute hep A on chronic hep B: +HBsAg, +IgM Anti-HAV

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22
Q

Acute hep A and hep B

A

+HBsAg, +IgM Anti-HAV, IgM Anti-HBc

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23
Q

Acute hep C

A

+Anti-HCV

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24
Q

Hep A

acute onset
causes
prophylazis
tx

A

Acute onset with 15-45 days incubation
• Causes: fecal oral transmission (eating or drinking), sexual activity
• Prophylaxis: inactivated vaccine
• Treatment: rehydration, rest, avoid alcohol, time

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25
Q

Hep B

incubation period
causes
prophylaxis
tx

A

Insidious or acute onset with a 1-6 month incubation
• Causes: percutaneous, perinatal, sexual
• Prophylaxis: HBIG vaccine, screen high risk populations
• Treatment: interferon, lamivudine, adefovir, pegylated interferon,
entecavir, telbivudine, tenofovir

26
Q

Hep C

onset
causes
vax
tx

A

Insidious onset with 15 days to 4 months incubation
• Causes: percutaneous, sexual
• No vaccine, screen high risk individuals
• Treatment: Pegylated interferon plus ribavirin, telaprevir, boceprevir

27
Q

Hep D

where is it found
incubation period
causes
prophylaxis
tx
A

Usually found in Mediterranean countries, in US found in those with
frequent blood transfusions
• Insidious or acute with 1 – 6 month incubation period
• Causes: percutaneous, perinatal, sexual
• Prophylaxis: HBV vaccine
• Treatment: Pegylated interferon

28
Q

Hep E

where found
transmitted
acute onset/incubation prophylaxis
tx

A

Found in India, Asia, Africa, Middle East, Central America.
• Transmitted through water contamination
• Acute onset with 2 week to 2 months incubation
• Prophylaxis: vaccine only in China
• No treatment

29
Q

Acute Pancreatitis

definition 
causes
S/S
Exam
Dx
A

Pancreatic inflammation
• Causes: Gallstones, ETOH, hypertriglycideremia (> 1000 mg/dl),
ERCP, medications, trauma, post-op abd surgery, connective tissue
disorders, Ca, inc calcium, cystic fibrosis, autoimmune, idiopathic
• S/S: abdominal pain, n/v, abdominal distention
• Exam: fever, tachy, hypotension, shock
• Diagnostics: amylase (elevated for 3-7 days), lipase (elevated for 7-14
days), CBC (inc WBC), hyperglycemia, hypocalcemia, inc LFTs, abd US
in ED

30
Q

early acute phase of pancreatitis

A

Early acute phase – less than 2 weeks, most patients have SIRS and
will become septic if not recognized early, older, obese and multiple
comorbid conditions put patient at greater risk

31
Q

Late acute phase of acute pancreatitis

A

• Late acute phase – greater than 2 weeks, complications arise from
early acute phase and now need to be treated

32
Q

Severity of acute pancreatitis

A

Severity of acute pancreatitis
• Mild – no local complications or organ failure, resolves 3-7 days with
treatment
• Moderate – transient organ failure resolving in less than 48 hours
• Severe – persistent organ failure, > 48 hours, local complications noted

33
Q

Tyes of pancreatitis by ct Interstitial

A
Diffuse gland enlargement
• Homogenous contrast
enhancement
• Mild inflammatory changes
• Peripancreatic stranding
34
Q

types of pancreatitis by CT necrotizing

A
Necrotizing
• Takes several days to evolve
• Lack of pancreatic parenchymal
enhancement with IV contrast
on CT
• Peripancreatic necrosis
35
Q

treatment of acute pancreatitis

A

Mild severity – full liquid diet once nausea and vomiting subside, low fat diet
• Aggressive IV fluids in the ED – LR or NS 15-20cc/kg bolused then 3mg/kg and hour afterwards, expect a drop in hct to determine if fluids are working
• Maintain UO at 0.5 c/kg/hour
• NPO
• IV pain meds
• Oxygen via NC
• ICU admission
• Treat underlying cause – gallstones > ERCP, inc trig > insulin, heparin or
plasmapheresis

36
Q

complications of acute pancreatitis

Local

A
Local
• Necrosis
• Fluid collections
• Pseudocyst
• Ascites
• Splenic vein or portal vein
thrombosis
• Bowel infarction
• Obstructive jaundice
37
Q

complications of acute pancreatitis systemic

A
Systemic
• Pulmonary
• CV
• DIC
• GI bleed
• Renal – ATN, oliguria,
thrombosis
• AMS
• Metabolic - encephalopathy
38
Q

chronic pancreatitis

definition
causes TIGAR-O

A
Irreversible damage to the
pancreas from reversible
changes in acute pancreatitis
• Causes: TIGAR-O classification
• T = toxic-metabolic
• I = idiopathic
• G = genetic
• A = autoimmune
• R = recurrent pancreatitis
• 0 = obstructive
39
Q

chronic pancreatits

s/s
D/x
TX
Complications

A
S/S: see acute slide
• Diagnostics: see acute slide in
addition, CT then MRI, secretin
test has best sens/spec
• Treatment: Pancreatic enzymes
• Complications: chronic pain,
narcotic addiction, DM,
gastroparesis, malabsorption,
jaundice, retinopathy, pancreatic
CA, cirrhosis, metabolic bone ds
40
Q

chrons disease

can effect....
s/s
dx
exam
tx
complications
A

Can affect any part of the GI tract, rectum is spared, transmural
process, aphthoid ulcerations and focal crypt abscesses with loose
aggregations of macrophages
• S/S: acute or chronic bowel inflammation, RLQ pain, diarrhea, colicky,
low grade fever, weight loss, fear of eating, anorexia
• Exam: inflammatory mass palpated, urinary obstruction
• Diagnostics: CBC, CRP, CMP, ESR, endoscopy (capsule is best),
• Treatment: IV fluids and bowel rest, replace electrolytes
• Complications: fistulas, adhesions, perforation

41
Q

UC

mucosa is…
s/s
dx
complications

A

Mucosal disease involving the rectum and all parts of the colon
• Mucosa is erythematous and resembles sandpaper, severe cases
hemorrhage is present, edematous and ulcerated
• S/S: rectal bleeding, tenesmus, passage of mucus, crampy abd pain,
proctitis
• Diagnostics: similar to Crohn’s, barium enema, sigmoidoscopy during
flare, colonoscopy if in remission
• Complications: toxic colitis, megacolon, perforation

42
Q

diverticulitis or osis

…..herniation

complicacated
uncomplicated
tx
surgical management

A

Saclike herniation in the bowel wall, generally left and sigmoid colon,
causing inflammation
• Determine if complicated or uncomplicated
• Uncomplicated: abdominal pain, fever, leukocytosis, anorexia
• Complicated: abscess, perforation, stricture, fistula
• Treatment: diet alterations and increase fiber for uncomplicated,
bowel rest and Bactrim or Cipro and Flagyl for complicated
• Surgical management: Diverting colostomy, Hartman’s procedure,
patients who are not responding medically

43
Q

GIB

causes
s/s
exam
dx
tx
A

Hematemesis or hematochezia
• Causes:
• UGI: PUD, gastritis, varices, Mallory-Weiss Tear (retching), AV malformation, malignancy, liver disease
• LGI: hemorrhoids, diverticulosis, AV malformation, colitis
• S/S: bright red blood, coffee ground, clots, retching, melena, blood in toilet, black
stool
• Exam: orthostatic, fatigue, exertional dyspnea, cool, clammy skin, pallor
• Diagnostics: fecal occult blood test, CBC, CMP, coags, Type and cross, LFTs, EGD, colonoscopy*, bleeding scan
• Treatment: stop bleeding, NGT unless contraindicated, blood transfusion, large
bore IV for fluids, foley • Varices: octreotide, banding, TIPS (shunt), balloon tamponade, IV PPI, empiric abx

44
Q

GERD

defnition
causes
s/s
dx
tx
complications
A

• Refluxed gastric acid and pepsin cause necrosis of the esophageal
mucosa causing erosions and ulcers.
• Causes: eosinophilia, infectious, herpetic, CMV
• S/S: heartburn, dysphagia, chest pain
• Diagnostics: endoscopy
• Treatment: lifestyle modifications, PPI, H2 blocker
• Complications: chronic esophagitis, adenocarcinoma, Barrett’s
esophagus

45
Q

mesenteric ischemia

definition
causes
s/s
exam
dx
tx
A

• Perfusion fails to meet the metabolic demands of the intestines
resulting in ischemia
• Causes: heart disease, shock, cocaine overdose
• S/S: abdominal pain, n/v, diarrhea, anorexia, bloody stools
• Exam: decreased bowel sounds, abdominal distention
• Diagnostics: CBC, CMP, coags, ABG, amylase, lipase, lactate, LFTs,
cardiac enzymes, CT angio, colonoscopy, spiral CT
• Treatment: ICU management, laparotomy
, hydration, antibiotics,
oxygen
• Chronic: reduce risk factors

46
Q

PUD

definitions
causes
s/s
dx
tx
complicatons
A

Burning epigastric pain, worsened by fasting, relieved with eating
• Causes: H. Pylori, NSAIDs, COPD, CRI, tobacco use, older age, ETOH
use
• S/S: abdominal pain, bleeding, n/v, dyspepsia
• Exam: orthostatic, tachycardia, epigastric tenderness, rigid abdomen
• Diagnostics: barium swallow, endoscopy, H. pylori testing, biopsy
• Treatment: antacids, H2 blockers, PPI, sucralfate, bismuth,
prostaglandin analogue
• Complications: bleeding, perforation, obstruction

47
Q

H Pylori tx

A

Bismuth, metronidazole, tetracycline
• Ranitidine bismuth citrate, tetracycline, clarithromycin or
metronidazole
• Omeprazole, clarithromycin, metronidazole or amoxicillin
• Omeprazole, bismuth, metronidazole, tetracycline

48
Q

AKI

definition
causes
s/s
dx
tx
complications
A

Sudden impairment of kidney function, retention of waste products
• Causes: Prerenal, Intrinsic, Post-renal (see next slide)
• S/S: related to cause
• Diagnostics: serum Cr, rise of at least 50% than baseline 1 week prior,
0.3 mg/dl in 48 hours, or UO less than 0.5 ml/kg/hr in 6 hours
• Treatment: IV fluids, remove nephrotoxic agent, optimize
hemodynamics, treat underlying causes
• Complications: ARF

49
Q

pre-renal AKI

A
Prerenal
• Hypovolemia
• Decreased CO
• CHF
• Liver failure
• NSAIDs
• ACE
• Cyclosporine
50
Q

Intrinsic causes of AKI

A
Intrinsic
• Sepsis
• Ischemia
• Nephrotoxins esp
contrast
• Acute
glomerulonephritis,
• Vasculitis
• Malignant HTN
• Post operative
51
Q

post renal aki is

A

obstruction

52
Q

CKD

causes
dx
tx
complications

A

Progressive decline in GFR
• Causes: small for gest weight, obesity, HTN, DM, autoimmune, older
adults, African ancestry, family history, AKI in the past, inherited
• Diagnostics: GFR needed to stage CKD
• Treatment: depending on stage, treat underlying cause, adjust
medications, dialysis for ESRD
• Complications: electrolyte imbalances, metabolic acidosis, anemia

53
Q

CKD stake I

A

gfr >90

54
Q

CKD II

A

GFR 60-90

55
Q

CKD IIIa

A

GFR 45-59

56
Q

CKD 3B

A

GFR 30-44

57
Q

CKD 4

A

gfr 15-29

58
Q

CKD stage 5

A

gfr <15

59
Q

UTI causes

A
Can be symptomatic or asymptomatic
• Asymptomatic bacteriuria
• Cystitis
• Prostatitis
• Pyelonephritis
• Uncomplicated vs complicated
• CAUTI
• Causes: sexual intercourse, DM, incontinence, catheter, diaphragm with spermicide, pregnancy,
functional or anatomic abnormalities
60
Q

UTI bacteria

A

Bacteria: E. coli is predominant, Pseudomonas, Klebsiella, Proteus, Citrobacter, Acinetobacter, Morganella

61
Q

UTI
s/s
dx
tx

A

S/S: dysuria, urinary frequency, urgency, nocturia, hesitancy, pain, hematuria, fever, CVA pain
• Diagnostics: urine culture and urinalysis, CBC, blood culture
• Treatment: antibiotic based on cultures