GI Flashcards
1
Q
What is the most common cause of inherited pancreatitis?
A
Inability to deactive trypsin while still in the pancreas
- SPINK1 – serine peptidase inhibitor kaza 1
- Trypsin autocleavage, when activated will cleave other activated trypsins
2
Q
What is one of the most common complications of pancreatitis?
A
ARDS – due to endothelial damage from the loose enzymes leading to fluid infiltrating the alveoli
3
Q
If a patient has a celiac sprue, what might be expected on histology of biopsy?
A
– blunted intestinal villous
– crypt hyperplasia
– lymphocytic hyperplasia
(+) IgA Anti-endomysium
(+) Anti-Transglutaminase