GI

Question 1

What is the most common cause of inherited pancreatitis?

Answer 1

Inability to deactive trypsin while still in the pancreas

• • SPINK1 – serine peptidase inhibitor kaza 1
• • Trypsin autocleavage, when activated will cleave other activated trypsins

Question 2

What is one of the most common complications of pancreatitis?

Answer 2

ARDS – due to endothelial damage from the loose enzymes leading to fluid infiltrating the alveoli

Question 3

If a patient has a celiac sprue, what might be expected on histology of biopsy?

Answer 3

– blunted intestinal villous
– crypt hyperplasia
– lymphocytic hyperplasia
(+) IgA Anti-endomysium
(+) Anti-Transglutaminase