DNA Viruses Flashcards
What is the common classification among herpes family of viruses?
dsDNA enveloped
What is the most common cause of intraoral inflammation of the gingiva and mucosa in a young newborn?
HSV-1 (typically from the mother)
What virus is responsible for a 25 year old with fever, headache, personality change, and hallucinations?
Desiminated HSV-1
– temporal lobe inflammation and hemorrhages
Where do HSV-1 and HSV-2 reside latently?
HSV-1 – usually trigeminal ganglia
HSV-2 – sacral ganglia
What test would you need to perform after you have aspired at vessicular lesion on a patient’s groin to identify?
Tzank Smear – look for multinucleated giant cells and intracellular inclusions – Cowdry Bodies
What is characteristics of HSV-2 infection?
painful groin vesiscular lesions with inguinal lymphadepathy
What family and characteristics is EBV?
Herpesfamily
dsDNA with envelope
What are unique pathology associated with EBV?
Infects B-cells via CD21 Receptor
- Infectious Mono
Immunocompromised
- Hodgkin’s Lymphoma – Reed-Sternburg Cells
- Burkitt Lymphoma – jaw/mandible lesions
- Nasopharyngeal Carcinoma (Asians)
- leukoplakia of the lateral tongue (HIV)
How can you tell strep pharyngitis/tonsillitis from infectious mononucleosis?
Strep – usually young children and resolves with amoxicillin/ampicillin
EBV – older children (teens) and will have posterior LAD and if started on amox/amp will develop macular rash
What are the diagnostic tests for EBV / Infectious Mononucleosis?
Monospot Test – heterophile antibodies that bind to horse RBC (REMEMBER B-CELLS)
What is a unique microscopic identifier of Infectious mononucleosis?
- Downey Cells, mostly CD8+ cells with indented nucleus
What family is CMV in and how is it classified?
Herpesfamily, dsDNA virus with envelop
What are the buzz words for congenital CMV infection?
- sensorineural HEARING LOSS in children
- “blue berry muffin rash” – petechiae rash
- intraventrical calcifications
- Hydrops Fetalis
- – its the most common congenital viral infection
What kind of symptoms in a patient that has a CD4 count below 50, if infected with CMV?
- CMV Retinitis
- Linear Ulcerations of esophagitis
- CMV Colitis
What is the causative agent if a 15 year old gets pharyngitis with posterior LAD, but negative Monospot Test?
- Strep
- - CMV (Owl’s Eye Appearance)
What family is varicella zoster in and classification?
Herpesfamily – dsDNA with evelope
What is unique characteristic of varicella in children?
“Dew drops on a rose” – type of rash
- Different stages of healing (KEY)
- fever/sweat
What are the pathologic factors in varicella?
- Latent in dorsal root ganglia
Immunocompromised
– dermatomal distribution
– postherpetic neurologia (painful area with or without rash several weeks/months)
Complication – varicella pneumonia (mortality)