GI

Question 0

What is the pump involved in secretory diarrhoea?

Answer 0

CFTR

Question 1

What is secretory diarrhoea?

Answer 1

When chloride ions are secreted into the gut lumen by CFTR pumps, and water follows down the oncotic gradient.

Question 2

What is a possible cause of secretory diarrhoea?

Answer 2

Cholera

Question 3

What is hyper motility diarrhoea?

Answer 3

Bowel transit time is increased, resulting in decresaed endothelial contact and decreased absorption

Question 4

What is osmotic diarrhoea?

Answer 4

When the solutes in the lumen ARE NOT BROKEN DOWN so act as an osmotic driver, bringing water into the lumen instead of out of it. Different to secretory diarrhoea.

Question 5

What’s the difference between osmotic and secretory diarrhoea?

Answer 5

Osmotic: undirected solutes create an oncotic gradient, bringing water into the lumen.

Secretory: chloride is moved into the lumen through CFTR transporters, and this makes water also enter the lumen.

Question 6

What is inflammatory diarrhoea?

Answer 6

The inflammatory process causes the capillaries to become more permeable, and this causes diarrhoea.

Question 7

What are the signs of inflammatory diarrhoea?

Answer 7

Pain, blood and pus in stools, fever