GI Flashcards
what instructions would you give a patient about to take gaviscon alongside other drugs
don’t take it within 2 hours of other drugs as it affects absorption
especially e.g. tetracyclines, PPIs
what is the most common side effect of gaviscon
diarrhoea
mechanism of ranitidine
H2 receptor antagonist
so prevents histamine binding to H2 receptors
leads to decreased gastric acid production
what drug do you not give ranitidine with
warfarin
causes bleeding
ranitidine affects the absorption of warfarin
which organ metabolises omeprazole
liver
which GI drug gives you a chance of developing C. Diff Associated Diarrhoea
omeprazole
2 blood abnormalities associated with omeprazole
hyponatraemia
hypomagnesia
loperamide mechanism
anti-diarrhoeal
opioid receptor agonist
decreases acetylcholine and prostaglandin release
decreasing frequency of peristalsis
so water has more time to be absorbed
what 3 times do u not give loperamide
blood in stool
mucous in stool
UC exacerbation
2 interactions of loperamide
anti-depressants e.g. sertraline
opioid analgesics e..g codeine
mx for chronic constipation
1st line: bulk forming with plenty of oral fluid e.g. ispaghula
2nd line: add softener e.g. docusate
3rd line: add a stimulant e.g. Senna
4th line: add an osmotic e.g. laculose
which specific laxative should you not give in IBS
Laculose as makes you gassy (osmotic)
can use the other type of osmotic e.g. macrogol
what 3 conditions should u not give laxatives in
toxic megacolon
paralytic ileus
GI obstruction
which laxative does mesalazine interact with
laculose
as laculose reduces the effect of mesalazine
mechanism of metclopramide
anti-emetic
dopamine and serotonin antagonist
motility agent- opens the pyloris (stretched stomach causes nausea)
has small effect on the vomiting centre in the brain
