GI 06 Flashcards
(41 cards)
How many ways we can be able to treat the condition of GI tract?
2 ways
Oral and Rectal
Why do we need to think about drug formulation for treating GI disorders?
Transit time: Because the material will move through the intestine at different rates depends on their formulation like solid or liquid.
pH: because the stomach is more acidic where is the next part of the GI ph. reduce slowly.
Omeprazole is used to treat
Ulcer and GORD
Funded brand in NZ is
Omeprazole Activis. Omeprazole is Oral capsule form with gelatine capsule
With enteric coated granules.
What is MUPS ?
Its abbriviation is Multi Unit Pellet system.
This enteric coated granules system called MUPS
How omeprazole absorb and work ?
Omeprazole absorbs into our small intestine then systemically goes near the pumps into our stomach and it binds in a low acidic environment (prodrug) with the pump irreversibly and covalently. In our blood it stays inactive then comes near CRYPTS of gastric mucosa and than activate from the prodrug in the presence of low acidic environment.
Where proton pump inhibitor (Omeprazole) works?
Pump
Does omeprazole is Acid labile or Base labile ?
Acid labile because
In higher pH the degradation rate of omeprazole is lower.
In lower pH the degradation rate of omeprazole is higher.
Calculate the t90 for omeprazole degradation at pH 7.0 and 10.0 at 25 degree Celsius.
So remember if the drug degradation occur in a linear rate its first order rate e degradation.
Y axis is= rate of degradation in the graph. X is in different pH .
So Y= -0.69x+4.5
Remember to put, log k = - 0.69 pH + 4.5
Therefore, log k= -0.69x7+ 4.5
k= - 0.33 (If we take out the log)
k= 0.4677
k=0.47 (Now we got K)
T90 =0.105/k
T90=0.105/0.47
=0.22 days
Now calculate the t90 for Omeprazole at pH 10 at 25 degree Celsius
Need to do
How stable is omeprazole ?
By looking this table we can see that omeprazole is become precipitated in Low pH whereas in high pH or low acidic environment it has 100 percent effect.
How is omeprazole formulated ?
Tablet with enteric coated granules
Capsule filled with enteric coated granules.
What coating is required for a acid labile drug ?
Enteric coting because this coat will help to protect our acid labile drug.
What does the meaning of ‘Conventional’ mean ?
Immediate release
In which pH enteric coating breaks down ?
The enteric coating stay intact at low pH and release, break down at higher pH.
Why enteric cote?
Because it will maintain the formulation at low ph or High acidic environment.
And the enteric cote will protect our acid labile drug(omeprazole). SO it improves bioavailability.
Because our drug needs to go to small intestine which is the primary site for Omeprazole absorption or breaks.as the intestinal pH is higher and low acidic so drug will absorb or degrades or breaks a part.
All lime juice ph is around
2.something
Polymer used for enteric coating called:
Eudragid
Solubility of this polymers depends on pH.
In which pH PVAP (Polyvinyl acetate) become soluble?
is soluble at pH 5
In what pH the Shellac (polymer) become soluble ?
Is soluble in pH 7
Who might have problems of swallowing a tablet ?
Kids Parkinson's disease Radiotherapy in the neck area Kids Survivors of stroke
What if a patient can’t Swallow a omeprazole tablet ?
As pharmacist you might thing about other formulation type.like omeprazole capsule.
Or might think about Tube called Nasogastric tube by nose to stomach.
What is good about Nasogastric tube ?
Maintain stability of Omeprazole
Ensure correct dose
Volume need to be adjusted while administering.
To washing off the pellets what fluid we might use ?
lemon juice is better as they are low ph or high acidic.
