Get this down - Pharm 23 stuff (add more)

Question 1

-tidine

Answer 1

Histamine-2 receptor antagonists (H2RAs)

Question 2

index for Histamine-2 receptor antagonists (H2RAs)

Answer 2

ranitidine

famotidine

Question 3

-azole

Answer 3

Proton pump inhibitors (PPIs)

Question 4

index for Proton pump inhibitors (PPIs)

Answer 4

omeaprazole

then esomperazole, lansoprazole

Question 5

ADE of cimetidine (H2RA)

Answer 5

gynecomastia
drug interactions
HR changes

Question 6

Indications for ranitidine (H2RA)

Answer 6

§ Duodenal ulcer disease
§ Erosive esophagitis 
§ Gastric hypersecretion 
§ Gastric ulcer
§ GERD
§ H. pylori infection
§ Dyspepsia

Question 7

Use for calcium carbonate

Answer 7

calcium supplement
antacid
hyperphosphatemia in CKD

Question 8

What acid neutralizer disrupts the acid-base balance?

Answer 8

sodium bicarbonate

Question 9

SE of aluminum hydroxide (antacid)

Answer 9

§ Suppresses H. pylori defense
§ Hypophosphatemia
§ Renally cleared = anemia, neurotoxicity, renal failure
§ Reduced absorption of many medications

Question 10

famotidine vs. ranitidine

Answer 10

very similar and close

Question 11

PPI duration

Answer 11

Steady state in 5-7 days

Indicated for 2wks, 4wks, and up to 8-12wks

Question 12

PPI long duration problems

Answer 12

§ Patients on doses for >6 months results in hypergastrinemia or rebound

§ Can become very difficult to taper these patients off of these drugs

§ If on a moderate or high dose, decrease dose 50% weekly until at lowest possible dose

Question 13

PPI ADE

Answer 13

§ GI side effects possible
§ HA
§ Hypomagnesemia (More with high doses and in hypersecretory patients)
§ Gastric atrophy
§ Iron and B12 deficiencies

Question 14

Omeprazole drug interactions

Answer 14

Biggest interaction occurs with SSRI citalopram

• see citalopram toxicity
• serotonin syndrome
• QT prolongation

Also interact with clopidogrel: combo use decreases antiplatelet effects

Question 15

Benefit of pantoprazole

Answer 15

Lower risk alternative to omeprazole and clopidogrel combo

Question 16

Benefit of rabeprazole

Answer 16

Lower risk alternative to omeprazole and clopidogrel combo

Question 17

-setron

Answer 17

5-hydroxytryptamine (serotonin)-3 receptor antagonists anti-emetics

Question 18

-pitant

Answer 18

Substance P/neurokinin-1 antagonists

Question 19

-azine & -amide

Answer 19

Dopamine-2 receptor antagonists

Question 20

drug causing tardive dyskinesia in about 12 weeks

Answer 20

metoclopramide (Dopamine-2 receptor antagonists)

Question 21

-mine

Answer 21

antimuscarinic GI antispasmodic

Question 22

indications for metoclopramide

Answer 22

GERD (<12wks or = TD)
Diabetic gastroparesis
Chemotherapy induced/Post-OP N/V