Gestational Trophoblastic Disease GTD

Question 1

Define gestational trophoblastic disease

Answer 1

Spectrum of pregnancy related neoplastic conditions that may be benign (molar pregnancy/ hydatiform mole ) or malignant (choriocarcinoma)
Due to abnormal proliferation of placental trophoblasts

Question 2

Define complete molar pregnancy

Answer 2

AKA complete hydatiform mole

Abnormally fertilised egg: ovum containing no maternal genetic material fertilised by one or two sperm so all genetics from paternal. Chromosomes from mother lost /inactivated and paternal chromosomes duplicated

Question 3

Define incomplete hydatiform mole

Answer 3

AKA incomplete molar

Maternal chromosomes remain but 2 sets of paternal chromosomes. Embryo has 69 chromosomes instead of 46. Usually when 2 sperm fertilise egg

Question 4

Name 3 types malignant gestational trophoblastic disease

Answer 4

• Choriocarcinoma!
• Placental site trophoblastic tumour PSTT
• epitheloid trophoblastic tumours ETT

Question 5

Name 3 common sites metastasis choriocarcinoma

Answer 5

• Lungs
• brain
• liver
• vaginal

Question 6

What do placental site tumours and epitheloid trophoblastic tumours produce

Answer 6

Human placental lactogen