Geriatrics

Question 1

Physiologic changes that accompany aging can result in altered pharmacokinetics include

Answer 1

Increase in body fat

Decrease in lean body mass

Increased distribution of FAT soluble drugs such as diazepam increasing the drugs half life

Decreased glomerular filtration rate

ABSORPTION OF DRUGS CHANGES VERY LITTLE WITH ADVANCING AGE

Question 2

Hallmarks of Alzheimer’s dementia

Answer 2

Memory loss plus

Aphasia- can’t come up with words
Apraxia- difficulty using utensils
Agnosia- lost in familiar surroundings
Executive dysfunction - can’t manage checkbook

Question 3

Dementia, Parkinsonism and visual hallucinations most likely diagnosis

Answer 3

Diffuse Lewy body dementia

Question 4

Rapidly progressive dementia with myoclonus developed over several months

Answer 4

Creutzfeldt Jakob disease

Question 5

Drugs if choice to treat delirium

Answer 5

Antipsychotics

Haloperidol