Geriatrics Flashcards
What are clinical features of delirium?
Disorientation
Hallucinations
In attention
Memory problems
Mood/personality changes
Poor sleep
What are causes of delirium?
Drugs – alcohol, anticholinergics, opiates, anticonvulsants, recreational drugs
Infection (particularly UTIs)
Urinary or faecal retention
Ictal
Dehydration/malnutrition
Metabolic
Low output state (MI, IDS, PE, CHF)
How is delirium treated?
Treat underlying cause
Haloperidol or Olanzapine can be given
If the patient has Parkinson’s them the drug of choice is Lorazepam
What medication can be given to treat delirium in a patient with Parkinson’s?
Lorazepam
How can you differentiate between delirium and dementia? What are features which favour delirium?
Impaired consciousness
Fluctuation of symptoms
Abnormal perceptions e.g. hallucinations
Agitation
Fear
Delusions
What is the most common form of dementia?
Alzheimer’s disease
What are features of Alzheimer’s?
The four A’s
Amnesia (memory loss)
Aphasia (inability to speak/understand)
Agnosia (inability to recognise/identify objects)
Apraxia (inability to perform learned movements)
What pathological changes are seen in Alzheimer’s disease?
Widespread cerebral atrophy
Cortical plaques
Acetylcholine deficiency
How is Alzheimer’s disease managed?
Cognitive stimulation
1) Acetylcholinesterase inhibitor – donepezil/galantamine/rivastigmine
Note that donepezil is contraindicated in bradycardia
2) Memantine if acetylcholinesterase inhibitors are CI/not tolerated (caution in history of epilepsy)
What are features of Lewy body dementia?
Progressive cognitive impairment
Early impairments in attention and executive function
Fluctuating cognition
Parkinsonism
Visual hallucinations
How can we differentiate Lewy body dementia from Alzheimer’s?
Lewy body dementia also has parkinsonism and visual hallucinations
Alzheimer’s has memory loss only in the early stages Lewy body dementia also has early impairment of executive function
How is Lewy body dementia managed?
Acetylcholinesterase inhibitor e.g. donepezil/rivastigmine
Galantamine is not licensed in Lewy body dementia
Which acetylcholinesterase inhibitor is not licensed in Lewy body dementia?
Galantamine
What are features of vascular dementia?
Presents in patients with risk factors – AF/hypertension/diabetes/smoking/obesity
Maybe history of stroke
Presents as stepwise deterioration
How is vascular dementia treated?
Reduce risk factors
Symptomatic treatment