Cardiology Flashcards
What is the initial management of acute coronary syndrome?
300mg aspirin
Oxygen if sats below 94%
IV Morphine if severe pain
Nitrates
ECG
What is the criteria for a STEMI on ECG?
> 2mm in two or more chest leads
1mm in two or more limb leads
New LBBB
How is a STEMI managed?
First decide whether PCI can be done in 120 mins
If yes - give prasugrel + aspirin (clopidogrel + aspirin if already on an anti-coagulant)
During PCI give unfractionated heparin + glycoprotein IIb/IIIa
If not - thrombolyse with alteplase. also give fondaparunix
After the procedure give ticagrelor + aspirin (or clopidogrel + aspirin if already anti coagulated)
How is an NSTEMI managed?
300mg loading dose Aspirin
Fondaparunix (unless immediate PCI)
Conduct a risk score e.g. Grace score
If risk = less than 3% - give ticagrelor + aspirin (if already on anticoagulant, clopidogrel + aspirin)
If risk = more than 3% = PCI within 72 hours
Unless haemodynamically unstable then immediate PCI.
+ Give prasugrel/ticagrelor + aspirin (clopidogrel if already on an anticoagulant)
+ Give unfractionated Heparin
What are the two types of tachycardia?
Narrow complex and broad complex
Which type of tachycardia is more serious?
Broad complex
What are causes of narrow complex tachycardia?
Sinus tachycardia
Supraventricular tachycardia
Atrial fibrilliation
What are causes of broad complex tachycardia?
If regular - ventricular tachycardia
If irregular - AF + BBB
How is supraventricular tachycardia managed?
1st line = Vagal manoeuvre (e.g. valsalva manoeuvre or carotid sinus massage)
2nd line = IV adenosine, 6mg then 12mg then 18mg
How is ventricular tachycardia managed?
If hypotensive/chest pain/heart failure - immediate cardioversion
Otherwise - Amiodarone (loading dose + 24 hour infusion)
How does atrial fibrillation present on an ECG?
Irregularly irregular rhythm
Absence of P wave
Narrow complex
What are the different types of atrial fibrillation ?
First detected episode Recurrent episodes Paroxysmal AF persistent AF Permanent AF
What symptoms can atrial fibrillation present with?
Palpitations
SOB
Chest pain
Dizzines
What are indications for rhythm control over rate control in AF?
First presentation of AF
Coexisting heart failure
Obvious reversible cause
Or, still symptomatic despite rate control
Which medication is used for rate control AF?
First line = BB (Atenolol)
Second line = CCB (Verapamil/Diltiazem) - avoid in heart failure (not in combination with BB)
Third line = Digoxin (used for people who also have heart failure)
What drugs are used for pharmacological cardioversion in AF?
Amiodarone or Flecainide
When is Flecainide CI?
Structural heart disease
Post myocardial infarction
Atrial flutter
When can cardioversion be done immediately and when does it need to be delayed in AF?
If AF began less than 48 hours ago - immediate cardioversion
If AF began over 48 hours ago - anticoagulate for 3 weeks then cardioversion
How do you decide which people with AF require anticoagulation?
Cha2ds2vasc score
Congestive heart failure Hypertension Age >75 = 2, age 65-74 = 1 Diabetes History of stroke/TIA/embolism = 2 Vascular disease Sex (female)
If men - anticoagulants with 1 point
Women - needs 2 points
What is the anticoagulant of choice in people with AF?
DOAC - rivaroxaban/apixaban/dabigatran/edoxaban
If valvular AF - Warfarin
If someone with AF has a cha2ds2vasc score of 0 (or 1 in women), what do you need to make sure before not anticoagulating them?
Conduct an echo
If they have a valvular heart disease they need to be put on an anticoagulant
ST elevation in leads V3 and V4 indicate what type of MI?
Anterior
ST elevation in leads I, avL, V5 and V6 indicate an MI in which territory?
Lateral
ST elevation in leads II, III and avF indicate a MI in which territory?
Inferior
ST elevation in leads V1 and V2 indicate an MI in which territory?
Septal
What are the main causes of chronic heart failure?
Coronary heart disease or hypertension
How does chronic heart failure present ?
Dyspnoea Frothy pink sputum Orthopnoea Paroxysmal nocturnal Dyspnoea Pitting oedema Wheeze Weight loss
Bibasal crackles on examination
Raised JVP
Hepatomegaly
What is the first line investigation in chronic heart failure?
NT-proBNP
What is classed as a high NT-proBNP
> 2000
What is classed as a raised NT-proBNP?
> 400
What do we do with a raised/high NT-proBNP?
Raised - echo within 6 weeks (>400)
High - echo within 2 weeks (>2000)
What ECG changes can be seen in chronic heart failure?
Left axis deviation
P wave abnormalities
What chest X-ray signs are seen in chronic heart failure?
ABCDE Alveolar oedema Kerley B lines Cardiomegaly Dilated upper lobe vessels Pleural effusion
What is the first line management for CHF?
Beta blocker (usually Bisoprolol) + ACEi
Which drugs may you need to consider stopping in CHF?
Calcium channel blockers - can depress cardiac function and exacerbate symptoms
Tricyclic antidepressants
NSAIDs - risk of decompensation
Corticosteroids
QT prolonging medication
What condition causes pleuritic pain, pleural effusion and fever 2-6 weeks after an MI?
Dressler’s Syndrome
How is Dressler’s Syndrome managed?
NSAIDs
How does a left ventricular free wall rupture present?
How is it managed?
Raised JVP, pulsus paradoxus, diminished heart sounds
1-2 weeks after MI
Urgent pericardiocentesis + thoracotomy
How is left ventricular free wall rupture managed?
Urgent pericardiocentesis + thoracotomy
How is angina managed?
Prescribe everyone a statin and aspirin 75mg daily (secondary prevention)
Consider ACEi if diabetes + angina (secondary prevention)
Prescribe GTN spray to use when needed
First line treatment = BB or CCB (for the angina)
How does acute heart failure present?
Symptoms:
Breathlessness
Oedema
Fatigue
Signs: Cyanosis Tachycardia Tachypnoea Raised JVP Displaced apex beat Bibasal crackles Wheeze S3 heart sound
How is acute heart failure managed?
IV Furosemide
If oxygen sats below 94% - oxygen
respiratory failure - CPAP
What is stage 1 hypertension?
A reading of >140/90 in clinic or >135/85 on home average
What is stage 2 hypertension?
A clinic reading of >160/100 or home average reading of >150/95
What is classed as severe hypertension?
A systolic of 180 or a diastolic of 110
When should you offer drug treatment for stage 1 hypertension?
If the patient is over 80 plus has one of the following:
Target organ damage
Established cardiovascular disease
Renal disease
Diabetes
10 year cardiovascular risk of 10% or over
What murmur is associated with aortic regurgitation?
Early diastolic murmur
Heard best with patient leaning forwards
What other features are seen in aortic regurgitation?
Collapsing pulse
Wide pulse pressure
Quincke’s sign (pulsation of nail bed)
de Musset’s sign - Head bobbing
What murmur is seen in aortic stenosis?
Crescendo-decrescendo ejection systolic murmur
What other features are seen in aortic stenosis?
Narrow pulse pressure Slow rising pulse Slow or absent S2 S4 sound Thrill
(Ejection systolic crescendo decrescendo murmur)
What is the most common cause of aortic stenosis in young patients under 60 years of age?
A bicuspid aortic valve
What is the most common cause of aortic stenosis in older patients over 60 years of age?
Degenerative calcification of the aortic valve
What is the most common cause of mitral stenosis?
Rheumatic fever
What murmur is characteristically seen in mitral stenosis?
A mid to late diastolic murmur of rumbling character
What other features are seen in mitral stenosis?
Loud S1 with opening snap
Low volume pulse
Malar flush
Atrial fibrillation
What ECG signs are seen in mitral stenosis?
P mitrale(bifid P wave)
What murmur is characteristically seen in mitral regurgitation?
Pansystolic murmur with a blowing/whistling character
What other features are seen in mitral regurgitation?
Soft S1
Widely split S2
S3 sound
What is rheumatic fever?
Reaction to a recent strep pyogenes infection (2 to 6 weeks ago)
How is rheumatic fever diagnosed?
Evidence of recent strep infection + either..
2 major criteria
OR 1 major + 2 minor criteria
What classes as evidence of recent strep infection in rheumatic fever?
Increased strep antibodies
Positive throat swab
What are the major criteria in rheumatic fever?
JONES - Joints, carditis, nodules, erythema marginatum, Sydenham’s chorea
Erythema marginatum (rash on body in shape of rings)
Sydenham’s chorea (muscle jerking)
Polyarthritis
Carditis and valvulitis
Subcutaneous nodules
What are the minor criteria in rheumatic fever?
Raised CRP or ESR
Pyrexia
Arthralgia
Prolonged PR interval
How is rheumatic fever managed?
Oral penicillin V and NSAIDs
What murmur is seen in a ventricular septal defect?
Ventricular septal defect has a pansystolic murmur
What is the most common form of cardiomyopathy?
Dilated cardiomyopathy
What can cause a broad QRS complex ?
Ventricular tachycardia
Bundle branch block (left or right)
Wolff-Parkinson White Syndrome
Hyperkalaemia
Hypothermia
Tricyclic poisoning
What is electrical alternans and what is the main cause of this?
QRS complexes alternate in height
Main cause = massive pleural effusion and cardiac tamponade
What is torsades de pointes?
A polymorphic ventricular tachycardia caused by long QT
What can cause torsades de pointes? (I.e. what can cause long QT?)
Low calcium
Low potassium
Low magnesium
Hypothermia
Raised ICP
Medications - tricyclic antidepressants, erythromycin
What can cause a short QT?
Hypercalcaemia
Digoxin
What are causes of RBBB?
Right ventricular hypertrophy
PE
MI
How are palpitations investigated?
First line = ECG and bloods (U+Es, FBC, TFTs)
2nd line = Holter monitoring
How is acute Bradycardia managed?
If in shock/syncope - IV 500 micrograms Atropine (up to max 3mg)
If atropine fails -
1) transcutaneous pacing
2) isoprenaline/adrenaline infusion
3) transvenous pacing
What are causes of acute bradycardia?
Sinus or AV node disease
Drug induced - beta blockers, CCB
Electrolyte abnormalities
Hypothyroidism
How does an “innocent murmur” present?
Asymptomatic
Systolic
Loudest in pulmonary area
Blowing
Vary with position
Which anticoagulant is used in a patient with a prosthetic heart valve?
Warfarin
DOACs are contraindicated
Which congenital conditions are associated with a ventricular septal defect?
Down’s Syndrome
Edward’s syndrome
Patau syndrome
What murmur is seen in an atrial septal defect?
Ejection systolic murmur loudest on inspiration
Widely fixed splitting of S2
Murmur: ejection systolic murmur loudest on inspiration, fixed splitting of S2
Atrial septal defect
Murmur: ejection systolic murmur, crescendo-decrescendo
Aortic stenosis
Which murmur is associated with a narrow pulse pressure and a slow rising pulse?
Aortic stenosis
Murmur: early diastolic murmur, collapsing pulse and wide pulse pressure
Aortic regurgitation
Murmur: rumbling mid to late diastolic murmur with opening snap
Mitral stenosis
Which facial sign is seen in mitral stenosis?
Malar flush
Murmur: whistling pan systolic murmur with soft S1 and widely split S2
Mitral regurgitation
Which valve is most commonly affected by infective endocarditis?
Mitral valve
In IVDU - tricuspid valve
What are risk factors for infective endocarditis?
History of rheumatic heart disease
Prosthetic valve
Congenital heart defects
IV drug user
What is the most common causative organism of infective endocarditis?
Staph aureus
In patients who have had recent valve surgery in last 2 months - staph epidermidis
Which criteria is used to diagnose infective endocarditis?
Modified Duke Criteria
Need 2 major OR 1 major + 3 minor OR 5 minor
What are the 2 major criteria in infective endocarditis?
Positive blood culture
Evidence of endocardial involvement (positive echo or new valvular regurgitation)
What skin signs can be seen in infective endocarditis?
Splinter haemorrhages
Janeway lesions
Petechiae
Osler’s nodes
What are the minor criteria of infective endocarditis? (5)
Predisposing heart condition or IVDU
Fever
Vascular phenomena (petechiae, Janeway lesions)
Immunological phenomena (glomerulonephritis, osler’s nodes, Roth spots)
Microbiological evidence which does not meet major criteria
What is the antibiotic management used in infective endocarditis?
Initial (no blood cultures): Native valve = amoxicillin, prosthetic valve = vanco + rifampicin + gent
Staph aureus: native valve = flucloxacillin, prosthetic valve = flucloxacillin + rifampicin + gentamicin
MRSA: Vanc + Gent
What is the most common form of cardiomyopathy overall?
Dilated cardiomyopathy
What is seen on CXR in dilated cardiomyopathy?
Balloon appearance of heart
What are features of dilated cardiomyopathy?
Features of heart failure - breathlessness, oedema, raised JVP, paroxysmal nocturnal dyspnoea, orthopnoea
Systolic murmur
S3 sound
What is the most common congenital cardiomyopathy ?
Hypertrophic obstructive cardiomyopathy
What inheritance pattern does hypertrophic cardiomyopathy have?
Autosomal dominant
What murmur is seen in hypertrophic cardiomyopathy?
Ejection systolic murmur loudest at the lower left sternal edge
What signs are seen in hypertrophic cardiomyopathy?
Ejection systolic murmur
Jerky pulse
Displaced apex beat
Apical thrill
Which medications should be avoided in hypertrophic cardiomyopathy? Why?
ACEi
Nifedipine
Nitrates
These medications reduce preload or afterload and can possible aggravate outflow tract obstruction
What is Brugada syndrome?
A genetic condition caused by sodium channelopathies - common cause of sudden cardiac death
What is the diagnostic criteria for Brugada syndrome?
VF / polymorphic VT (torsades de pointes)
Family history of sudden cardiac death
Syncope
Nocturnal agonal breathing (sounds like gasping/snorting)
What are risk factors for sudden cardiac death in Brugada syndrome?
Fever
Excess alcohol intake
Dehydration
Hypokalaemia
Hypomagnasaemia
What is pericarditis?
Inflammation of the pericardium
What are features of pericarditis?
Pleuritic chest pain (relieved by leaning forwards)
Pericardial rub
Fever
Tachycardia
Tachypnoea
What are causes of pericarditis?
Viral infections (e.g. Coxsackie)
TB
Trauma
Post-MI
Dressler’s Syndrome
Hypothyroidism
Malignancy
What ECG changes are seen in pericarditis?
Saddle shaped ST elevation
PR depression
ECG changes are global (not in a specific territory)
How is pericarditis diagnosed?
Transthoracic echo
How is pericarditis managed?
NSAIDs + colchicine
Treat any underlying cause
What is constrictive pericarditis?
The pericardium becomes hard and thickened - this then interferes with ventricular filling
What causes constrictive pericarditis?
Any cause of pericarditis but especially TB
What are features of constrictive pericarditis?
Can present with symptoms of right sided heart failure - Dyspnoea, elevated JVP, Hepatomegaly, oedema
Pericardial knock (loud S3)
Positive Kussmaul’s sign (raised JVP that doesn’t fall on inspiration)
How is constrictive pericarditis managed? What if the initial management doesn’t work?
NSAIDs + colchicine
If no improvement -> pericardiectomy
What is a pericardial effusion?
Collection of fluid within the pericardial sac - commonly occurs with pericarditis
Can be blood, fluid, exudate, air
What is a cardiac tamponade?
An accumulation of fluid in the pericardium which is putting pressure on the ventricles
Associated with pericarditis
What triad is seen in cardiac tamponade?
Beck’s triad
Hypotension, raised JVP, muffled heart sounds
What are signs of cardiac tamponade?
Hypotension
Raised JVP
Muffled heart sounds
Dyspnoea
Tachycardia
Absent Y descent on JVO
Pulsus paradoxus (abnormally large drop in BP during inspiration)
What ECG change is seen in cardiac tamponade?
Electrical alternans (alternating QRS amplitude)
How is cardiac tamponade managed?
Pericardiocentesis
Which DOAC can be reversed and what is used for reversal?
Dabigatran
Reversed with Idarucizumab
What are contraindications to adenosine?
Asthma/COPD
Heart failure
Heart block
Severe hypotension
How is torsades de pointes treated?
IV Magnesium sulfate, Cardioversion
How can raised ICP show on an ECG?
Long QT
What ECG change can be seen in rheumatic fever?
Prolonged PR interval
How does acute mitral regurgitation after an MI present? And what causes it?
Caused by ischaemia or rupture of the papillary muscle
Can present with acute hypotension and pulmonary oedema
Early to mid systolic murmur
If a patient has persistent ST elevation after their myocardial infarction what complication have they sustained?
Left ventricular aneurysm
Which medications can decrease INR in a patient taking warfarin?
Phenytoin, carbamazepine
Rifampicin
St John’s wort
Chronic alcohol intake
Smoking
Which medications can increase INR in a patient taking warfarin?
Ciprofloxacin
Clarithromycin/erythromycin
Isoniazid
Omeprazole
Amiodarone
Allopurinol
Ketoconazole/fluconazole
SSRIs
Sodium valproate
Acute alcohol intake
What are indications for a pacemaker in a patient with acute bradycardia?
Complete heart block with broad complex QRS
Recent asystole
Mobitz type II AV block
Ventricular pause of more than three seconds
Which murmur is associated with Marfan’s?
Aortic regurgitation
Early diastolic murmur
Collapsing pulse
Wide pulse pressure
What ECG changes are suggestive of hypertrophic cardiomyopathy?
Left Ventricular hypertrophy
Non-specific T-wave inversions and ST segment abnormalities
Deep Q waves
What echocardiogram findings are found in hypertrophic cardiomyopathy?
MR SAM ASH
Mitral regurgitation
Systolic anterior motion
Asymmetric hypertrophy
How does hypertrophic cardiomyopathy usually present?
May be asymptomatic
Can be - exertional Dyspnoea, syncope typically following exercise, sudden death
What are the conditions is hypertrophic cardiomyopathy associated with?
Friedrichs ataxia
Wolff-Parkinson white
What further drugs can you consider adding in heart failure?
Aldosterone antagonist (spironolactone) - symptomatic relief only
Hydralazine + nitrate (especially in black/Caribbean)
Digoxin
Invabradine (if in sinus rhythm >75bpm and left ventricular fraction <35%)
What heart failure drug can be considered in black and Caribbean patients?
Hydralazine plus nitrate
What criteria must be met to prescribe ivabradine in heart failure?
> 75bpm
Left ventricular fraction <35%
Which vaccinations do those with heart failure require?
Annual influenza vaccine
One-off pneumococcal vaccine
When do beta blockers need to be stopped in heart failure?
Heart rate less than 50 BPM
2nd or 3rd degree AV block
Shock
What are adverse affects of adenosine?
Adenosine is used to treat supraventricular tachycardia
Adverse effects include chest pain and bronchospasm
Also transient flushing
Feeling of impending doom
Which patients is adenosine contraindicated in?
Asthmatics due to bronchospasm
How is stable angina treated?
- Beta blocker or Verapamil
2. Beta blocker + Nifedipine
How is AV block managed?
2nd degree heart block Mobitz type II and complete heart block both need transcutaneous pacing
1st degree + Mobitz type I = no treatment needed
What type of cardiomyopathy are alcoholics at risk of?
Dilated cardiomyopathy
Which leads does left circumflex artery affect?
I, aVL, +/- V5 and V6
What are the main side effects of ACE inhibitors?
Cough
Hyperkalaemia
What needs monitoring in patients taking ACE inhibitors and what are acceptable changes?
U&Es should be checked before treatment and after increasing dose
Rise in creatinine and potassium may be seen
Acceptable creatinine = 30% increase from baseline
Acceptable eGFR = 25% decrease
Acceptable potassium = up to 5.5mmol
What does significant renal impairment after starting an ACE inhibitor suggest?
How would that be diagnosed?
Undiagnosed bilateral renal artery stenosis
CT angio
What affect does ACE inhibitors have on the kidneys?
Vasoconstriction of afferent arteriole - Reduces glomerular blood flow
Not directly nephrotoxic but should be stopped in an AKI
Reno-protective in CKD
What is the major contraindication to Verapamil?
Ventricular tachycardia
Which valve is most commonly affected in infective endocarditis? What about in IVDUs?
Mitral valve
or Tricuspid valve in IVDUs
What is the mitral valve?
Valve from left atrium to the left ventricle
What is the aortic valve?
Valve from left ventricle to the Aorta
What is the tricuspid valve?
Valve from right atrium to the Right ventricle
What is the pulmonary valve?
Valve from right ventricle to the pulmonary artery
What is Kussmaul’s sign and what is it seen in?
Raised JVP which rises or doesn’t fall on inspiration
Seen in constrictive pericarditis
What is Beck’s triad and what condition is it seen in?
Raised JVP, muffled heart sounds, hypotension
Seen in cardiac tamponade
What is pulsus paradoxus and which heart problem is associated with this?
Abnormally large decrease in BP during inspiration
Cardiac tamponade
Also can be seen in obstructive lung disease e.g. Asthma/COPD
What should you consider in someone with a stroke/TIA/PE and a fever?
Infective endocarditis
How does a ruptured papillary muscle post-MI present?
Acute hypotension
Pulmonary oedema
Mitral regurg murmur
Which position is an aortic regurgitaton murmur heard best?
Patient leaning forwards
What is Quincke’s sign and what is it a sign of?
Nailbed pulsation
Seen in aortic regurgitation
What is De Musset’s sign and what is it a sign of?
Head bobbing
Seen in aortic regurgitation
What should you consider in a patient with tachycardia and tachypnoea but no other signs?
PE
What should be given instead of Adenosine for SVT in asthmatics?
Verapamil
Which condition is associated with differences in BP in each arm? How is it investigated?
Aortic dissection – CT angiogram showing a false lumen
What is the first line treatment for HTN in diabetes?
Black – ARB
Non-black – ACEi
What marker is raised in Dressler’s syndrome?
ESR
How does coarctation of the aorta present?
Systolic murmur loudest at LLSE
Weak pulses in the lower extremity
In adults can present with hypertension and notching of the inferior border of the ribs
What to do after fibrinolysis in STEMI?
Repeat ECG in 60-90 mins
If ST elevation not resolved – urgent PCI
Which artery is associated with a lateral MI?
Left circumflex/LAD
How to differentiate between Mobitz type 2 and complete heart block?
In Complete heart block – P-P interval and R-R interval will always be the same
In Mobitz type 2 – R-R interval will not be the same
How to manage a patient who has received a PCI but is still experiencing pain or haemodynamic instability?
Urgent CABG
When does infective endocarditis need surgical management?
If it is causing congestive cardiac failure
When does aortic stenosis require valve replacement?
Symptomatic
Asymptomatic + valvular gradient >40 + left ventricular systolic dysfunction
How to treat acute heart failure not responding to treatment?
Consider CPAP