Gentamicin Flashcards
How is a gent level calculated
Mg/ kg or via online calculator with creatinine clearance
What is a multiple daily dose regimen
If the guy is 70 kg and it was 3mg/kg he would be getting 210mg in 24 hours so he can get a single dose mixed with saline or he can get three 70mg doses in a day with saline
In a multiple daily dose how long should be waited between doses
8 hours
What is a safety caution on the BNF related to gentamicin
High levels of histamine in some batches leading to histamine related adverse reactions
What are the two main contraindications to gent
Myasthenia gravis
Patent grommet/ perforated membrane
What’s the most common side effects of gent
Tinnitus
Skin reactions
What are the two most important side effects to consider before prescribing gent
Ototoxocity
Nephrotoxicity
What should be checked before the first dose of gent
Creatinine clearance
A once daily regimen should be avoided in patients
With a creatinine clearance less than20ml/min
In a multiple daily dose regimen when should the gent blood level be taken
1 hour afternoon administration for peak and just before next dose for trough
If trough conc is high do what
Increase interval dose
If peak conc is high do what
Decrease dose
What else should be monitored during drug treatment
Auditory and vestibular function.
How is gent given
Mixed with saline
How does gent cause nephrotoxicity
Acute tubular necrosis
