Adverse drug reactions Flashcards
which drugs can worsen seizure control
alcohol, cocaine, amphetamines ciprofloxacin, levofloxacin aminophylline, theophylline bupropion methylphenidate (used in ADHD) mefenamic acid
which drugs can provoke seizures will being withdrawn
benzodiazepines, baclofen and hydroxyzine
which drugs may worsen seizure control by interfering with the metabolism of anti-epileptic drugs
p450 inducers/ inhibitors
which 5 drugs can exacerbate heart failure
thiazolidinediones - pioglitazone causes fluid retention
verapamil - has a negative inotropic effect
NSAIDS - cause fluid retention (exception to this is aspirin)
flecainide (negative inotropic and proarrhythmic effect)
Glucocorticoids - cause fluid retention
which hypertensive medication is contraindicated in pregnancy?
ACEI - TERATOGENIC
name 5 antibiotics contraindicated in pregnancy
tetracyclines
aminoglycosides
sulphonamides and trimethoprim
quinolones
name 6 other classes of drug contraindicated in pregnancy excluding ACEI and antibiotics
statins warfarin sulfonylureas retinoids (including topical) cytotoxic agents antiepileptics - valproate, carbemazepine, phenytoin
name three drugs contraindicated in asthma/ copd
nsaids - bronchospasm (if no alternative you can give them a trial period of NSAIDS but warn patients of risk)
beta blockers (not absolute contraindication so can be used under specialist control - cardioselective beta blockers may induce less side effects)
adenosine
what can be used as an alternative to adenosine in asthma/ copd
verapamil
when considering respiratory depression and COPD what do you need to consider
benzodiazepines and opioids
what four factors can precipitate psoriasis
trauma
alcohol
meds
withdrawal of systemic steroids
what infection can trigger guttate psoriasis
strep infection
what meds can trigger psoriasis
beta blockers, lithium, antimalarials (chloroquine and hydroxychloroquine), NSAIDs and ACE inhibitors, infliximab
