Antiemetics Flashcards
What are the indications for metoclopramide
Acute migraine
Delayed (not acute) chemo induced N+V
Radiotherapy induced N+V
Prevention of N+V post op
What is the most important piece of safety info for metoclopramide
It’s risk of neuro adverse effects such as extrapyramidal side effects and traduce dyskinesia
What are the contraindications for metoclopramide
Any GI surgery or haemorrhage or obstruction etc
Be careful with cardiac conditions and Parkinson’s
How do you treat dystonic attacks causes by metoclopramide
Antiparkinsosn drug such as procyclidine
What are the indications for cuclizine
N V Vertigo Motion sickness Vestibular stuff
When is levomepromazine used for N+V
Palliative care
What are the contraindications to levomepromazine
CNS depression comas
As is an antipsychotic cautioned in cardiovascular disease and postural hypotension
When can an antiemetic be prescribed
When a cause is known
What are the two main classes of drugs used as regular antiemetics not in palliative care
Antihistamines
Phenothiazines
What are phenothiazine
Dopamine agonists that block the chemoreceptor trigger zone
Which phenothiazines are less sedating
Prochlorperazine
Perphenazine
Trifluoperazine
What is the major problem with phenothiazines particularly in kids
Severe dystonic reactions
What is the best drug for nausea caused from GI tract
Metoclopramide
What is good for post of nausea and cytotoxic nausea
Domperidone
What are the main antiemetics used in pregnancy
Promethazine
Metoclopramide
Prochlorperazine
