Genomics Flashcards
1
Q
HLA-B 5701
A
abacavir fatal hypersensitivity
if positive, do not use abacavir
2
Q
HLA-B 5801
A
allopuriniol - risk of SJS/TEN
if positive, do not use allopurinol
3
Q
VKORC1
A
warfarin - increased bleeding
if positive, lower dose
4
Q
HER2
A
gene required for efficacy of trastuzumab, adotrastuzumab, emtansine, pertuzumab
5
Q
KRAS
A
only KRAS negative should receive cetuximab, panituzumab
6
Q
TPMT
A
low TPMT activity = increased myelosuppression w/ azathioprine
7
Q
DPD
A
deficiency = increased toxicity w/ capecitabine, fluorouracil
