Drug interactions Flashcards
1
Q
CYP inducers
A
PS PORCS phenytoin smoking phenobarbitol oxcarbazepine, eslicarbazepine rifampin, rifabutin, rifapentine carbameazepine St. John's wort
2
Q
CYP inhibitors
A
G PACMAN grapefruit protease inhibitors azole antifungals cyclosporine, cimetidine, cobicistat macolides - clarithromycin and erythromycin, NOT azithromycin amiodarone non-DHP CCBs - verapamil, diltiazem
3
Q
drugs causing serotonin syndrome
A
SSRIs, SNRIs, TCAs, MAOi, buspirone, DXM, fentanyl, methadone, lithium, mirtazapine, St. John’s wort, tramadol, trazadone
4
Q
opioids
A
do not use w/ 3A4 inhibitors = fatal respiratory depression
5
Q
PDE-5 inhibitors
A
do not use with nitrates
6
Q
statins
A
do not use with 3A4 inhibitors
rhabdomyolysis, muscle toxicity, CPK >10,000
7
Q
anticoag, antiplatelets
A
avoid SSRIs, SNRIs, ginkgo, garlic, ginger, glucosamine, ginseng
8
Q
ototoxicity
A
salicylates, vanc, aminoglycosides, cispatin, loop diuretics
