Genomic Instability Flashcards
Define genomic instability
change in cell’s DNA that make ADDITIONAL changes
in genomic mutations what usually gets mutated for cancer to occur
GATEKEEPERS
what starts neoplasm/cancert
mutagen/carcinogen
name two factors for initaiton of cancer
environment and genetics
what are some important implications that cancer has started
mutation is not corrected
not fatal to cell
mutation has advantage to cell
what are 3 features of neoplasm
uncontrolled replication
immortality
loss of DNA repair
how can cell loose control of replication
loss of tumor supressor cells
oncogenes turned on
has neoplasm progresses what does it do to genomic instability
increases genomic instability
metastatic subclone changes become more like what type of cell
mesenchymal
how does neoplasia start off as for replication? but what happens with further genomic instability
monoclonal
- growing neoplasm acquire different mutations
what is the difference between benign and malignant tumors
benign has less genomic stability
what happens to chemotherapy with subclonnes
different subclones respond differently chemotherapy
most chemotherapeutics do what to mutation
INCREASE
what is an advantage of targeted chemotherapy
reduces the chance of additional mutation
what are two flavors cancer can get genomic instability
macro and micro
