Epigenetics Flashcards
Characteristics of hypo methylated DNA
DNA is available for transcription
Genetically unstable
What do histone modifications do
Acetylation to make histones more or less positive
What does a more positive charge of histones do
DNA is more tightly bound
Less transcription
Chromatid-modifying enzymes
Changes packing of DNA to make it more or less available for transcription
miRNA targets what?
3’ UTR messenger RNA
When miRNA is bound to 3’ UTR messenger RNA, what happens
3’ UTR messenger RNA LESS STABLE and MORE LIKELY DEGRADED
REDUCES expression of gene it encodes
How do miRNA silence
Creating a double stranded RNA
RISC has what protein
DICER
What is the role of DICER
Recognize and degrade dsRNA
Keeps small piece to check with other RNA
What does DICER create
siRNA
Not complementary To coding mRNA
How does DICER create siRNA
Chops dsDNA to create siDNA, then silences complementary DNA
Define epigenetics
Alteration of gene expression without changes in gene’s nucleotide sequence
