Genome Organization Flashcards
Human genome is distributed on ____________
46 Chromosomes
Genotype + ______________= phenotype
Environment
There are _________ new mutations that occur in each individual.
30
Chromosome _______ is gene rich
19
Chromosomes ___, ___ and ____ are gene poor.
13, 18, and 21
______ of the genome is GC-rich.
38% of the genome
_______ is AT rich
54% percent
Clustering of _____ and ______ regions is the basis form chromosomal banding patterns
GC-rich/ AT-rich
Heterochromatic regions are more condensed and ___________
More repeat-rich
_________ % of the genome is translated
1.5%
Alpha-satellite repeats are found near the __________ region and important in chromosomal segregation; critical for attachment of chromosomes to microtubules of the spindle apparatus during cell division.
Centromeric
The dispersed relative elements include the __________ and the _____________ and can cause insertional inactivation of genes or abberant recombination events
Alu (short intersperse receptive elements) and L1 family (long interspersed receptive elements)
What are the four types of DNA variation?
- Minisatellites 2. Microsatellites, 3. Single Nucleotide Polymorphisms 4. Copy number variations
Genes often exist in families and arrive by gene _________ where one gene duplicates, freeing up one copy to vary while the other copy continues to carry out critical function.
Gene duplication
___________ are non functional. They may contain introns or could be intron-less if reverse transcriptase is used.
Psuedogenes
