Epigenetics

Question 1

Name the four main characteristics of epigenetic phenomena.

Answer 1

1. Different gene expression pattern/ phenotype, identical genome 2. Inheritance through cell division, even through generations 3. Like a switch: ON/OFF 4. Erasable (interconvertable

Question 2

What is Waddington’s principle?

Answer 2

Cell can take different pathways, both of which are stable.

Question 3

Periods of feast in the ______________ increased heart disease in grandchildren.

Answer 3

Paternal Grandfather

Question 4

When the AGOUTI gene is turned off, the mice were ___________

Answer 4

Darker and thinner

Question 5

When the AGOUTI gene was turned on, the mice were ___________

Answer 5

Blonder and fatter

Question 6

The AGOUTI gene activation was based on _________

Answer 6

Methyl donor ingredients in diet

Question 7

What it the order of imprinting/ erasure in cell replication?

Answer 7

1. Meiosis 2. Erasure 3. Sex-specific gene silencing through DNA methylation 4. Fertilization

Question 8

______________ (enzyme) propagate epigenetic marks through somatic cell division.

Answer 8

Maintenance Methyltransferase

Question 9

DNA methylation, which locks in the repressed state, occurs on __________

Answer 9

Cytocines of CpG

Question 10

____________ is an activating histone mark.

Answer 10

Acetylation of lysine

Question 11

Silencing of ___________ by 5meC can lead to cancer.

Answer 11

Tumor Supressor Gene (TSG)