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Path IV Final JT > Genital > Flashcards

Genital Flashcards

1
Q

MC cause of urethritis

A

Neisseria

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2
Q

2nd MC cause of urethritis?

A

Chlamydia

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3
Q

Urethritis following gonorrhea or chlamydia infx assoc with this dz

A

reactive arthritis

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4
Q

Name for rash on bottoms of feet in reactive arthritis

A

keratoderma blenorrhagica

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5
Q

Shallow painless ulcers at meatus and glans penis assoc with reactive arthritis

A

balanitis circinata

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6
Q

Infx agent in syphilis? Special stain?

A

Treponema pallidum (spirochete). Silver stain

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7
Q

Name for granulomatous growth in tertiary syphilis

A

gumma

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8
Q

Feature of secondary syphilis

A

palmar rash

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9
Q

HPV strains assoc with condyloma acuminata

A

6 and 11 (90%)

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10
Q

Woronoff’s ring

A

Ring of peripheral blanching around a psoriatic plaque

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11
Q

Female genital condition associated with white or pale thickening of skin of vulva

A

Lichen sclerosis

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12
Q 
Lichen Sclerosis or Lichen Planus?
A) Flattening or disappearance of rete pegs
B) Saw tooth appearance of rete pegs
C) Thickening of granular cell layer
D) Dermis replaced by CT
A

A) LS
B) LP
C) LP
D) LS

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13
Q

Histo of genital herpes

A

Nuclei have ground glass appearance

Multinucleated giant cells

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14
Q

MC birth defect of male genitalia

A

cryptorchism (undescended testes)

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15
Q

2nd MC birth defect of male genitalia. Explain what it is.

A

hypospadias (urethral opening on ventral aspect of penis)

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16
Q

What is the birth defect of male genitalia where urethral meatus opens on dorsum of penis?
Common or rare?

A

epispadias. rare

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17
Q

What is the condition where the foreskin cannot be fully retracted over the glans of the penis? Risk?

A

Phimosis. Penile CA

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18
Q

Condition where the foreskin becomes trapped behind the glans. Risk?

A

Paraphimosis. Penile CA

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19
Q

Varicocele, Hydrocele, or Torsion?
A) assoc with bell clapper deformity - congenital
B) fluid accumulation (secreted by tunica vaginalis)
C) 85-90% on left side
D) enlargement of vein draining testicles

A

A) Torsion
B) Hydro
C) Varico
D) Varico

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20
Q 
Urethritis: Gonococcal or non-Gonococcal?
A) purulent d/c
B) clear d/c
C) granulated cytoplasmic inclusions
D) chlamydia
A

A) Gono
B) Non-Gono
C) Non-Gono
D) Non-Gono

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21
Q 
% of testicular cancers
A) mixed
B) seminoma
C) embryonal carcinoma
D) teratoma
A

A) 40%
B) 35%
C) 10-20%
D) 5%

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22
Q 
Embryonal or seminoma testicular CA?
A) Alpha fetoprotein elevated
B) Assoc with placental alk phos (PLAP)
C) Elev hCG
D) Present in 90% of mixed tumors
A

A) embryonal
B) seminoma
C) embryonal (sometimes seminoma)
D) embryonal

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23
Q

MC solid malignant tumor in males 20-35 yo

A

Primary testicular tumors

24
Q

BV, Trich, or Candida?
A) fishy odor, high vaginal pH
B) foamy d/c
C) clue cells

A

A) BV and Trich
B) Trich
C) BV

25
BV, Trich, or Candida? A) itching, burning B) cottage cheese d/c C) odor absent, pH low
A) Trich, Candida B) Candida C) Candida
26
``` Chlamydia or Gonorrhea? A) polymorphic leukocytes B) friable C) caused by gram neg intra or extracellular diplococci D) causes pain on urination in males ```
A) N. gonorrhea B) Chlamydia C) N. gonorrhea D) Chlamydia
27
What are risk factors for cervical CA?
early age at first intercourse, multiple partners, male partner w/ previous partners, persistent detection of high risk HPV, presence of CA assoc HPV strains, OCP, tobacco, Hx of genital infx, multiparity
28
What HPV strains are MC associated with cervical CA?
16, 18, 31, 45 (mostly 16 and 18)
29
What genetic marker is associated with cervical CA?
HLA-B7
30
``` What Pap/CIN class? A) atypia, koilocytosis begins B) mild dysplasia C) moderate dysplasia D) severe dysplasia E) cancer ```
``` A) II B) III/CIN I C) III/CIN II D) III/CIN III E) V ```
31
Koilocytosis: CIN I, CIN II, or CIN III? A) diffuse atypia, loss of normal cell maturation B) widespread dysregulation of cell cycle controls C) enlarged nuclei, stain darkly w halo-like appearance D) upregulation of p16ink4 characterizes high risk HPV
A) CIN III B) CIN II C) CIN I D) CIN II
32
Histo of cervical carcinoma in situ
loss of maturation of squamous epithelium high nucleus to cytoplasm ratio hyperchromatic nuclei
33
Histo of endocervical CA
enlarged, prominent round or oval nuclei | irregular chromatin distribution
34
DNA poxvirus that infects skin or mucous membranes. Unlike herpes it does not remain in the body when the skin lesions are gone.
Molluscum contagiosum
35
Female genital condition assoc w incr risk of vulvar CA
Lichen sclerosis
36
Can syphilis be congenital?
Yes, can be vertical transfer
37
Condition with hyperpigmented skin plaques. Lesions of red, white, yellow, or multi-pigmented plaques.
VIN
38
More than 90% of cases of VIN are assoc w these strains of HPV
16, 18, 31, 45
39
MC site of implantation of ectopic endometrial cells
ovaries
40
Ovarian cyst that is formed as a consequence of ectopic endometrial tissue that bleeds within the ovary
endometrioma (chocolate cyst)
41
Presence of ectopic endometrial tissue within myometrium
adenomyosis
42
Characterized by the presence of micro-abscesses or neutrophils within the endometrial glands
acute endometritis
43
Characterized by the presence of plasma cells in the stroma
chronic endometritis
44
MC gynecologic CA in US.
endometrial CA
45
Most common type of endometrial CA?
adenocarcinoma
46
20% of endometrial CA are papillary serous carcinoma. These are assoc with what mutation?
p53 mutations
47
Discrete, well-circumscribed benign tumors often round, firm and gray white when sectioned
leiomyoma
48
MC type of ovarian tumor
serous cystadenoma, benign
49
Psammoma bodies are assoc with
ovarian serous cystadenoma
50
tumor with tissue or organ components resembling normal derivatives of more than one germ layer
teratoma
51
MC type of ovarian CA (what tissue)
epithelial (90%)
52
What is one way to differentiate between syphilis and genital herpes?
Lesions of syphilis are painless. Genital herpes very painful.
53
"string of pearls" appearance of cysts
PCOS
54
Lots of clear/pale cytoplasm, glycogen. lobular cells, intervening stroma, prominent nuclei and nuclear membranes
seminoma testicular CA
55
Crowded pleomrph nuclei, nuc atypia, mitosis common
embryonal testicular CA

Path IV Final JT (5 decks)

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