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Path IV Final JT > Genital > Flashcards

Genital Flashcards

1
Q

MC cause of urethritis

A

Neisseria

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2
Q

2nd MC cause of urethritis?

A

Chlamydia

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3
Q

Urethritis following gonorrhea or chlamydia infx assoc with this dz

A

reactive arthritis

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4
Q

Name for rash on bottoms of feet in reactive arthritis

A

keratoderma blenorrhagica

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5
Q

Shallow painless ulcers at meatus and glans penis assoc with reactive arthritis

A

balanitis circinata

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6
Q

Infx agent in syphilis? Special stain?

A

Treponema pallidum (spirochete). Silver stain

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7
Q

Name for granulomatous growth in tertiary syphilis

A

gumma

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8
Q

Feature of secondary syphilis

A

palmar rash

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9
Q

HPV strains assoc with condyloma acuminata

A

6 and 11 (90%)

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10
Q

Woronoff’s ring

A

Ring of peripheral blanching around a psoriatic plaque

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11
Q

Female genital condition associated with white or pale thickening of skin of vulva

A

Lichen sclerosis

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12
Q 
Lichen Sclerosis or Lichen Planus?
A) Flattening or disappearance of rete pegs
B) Saw tooth appearance of rete pegs
C) Thickening of granular cell layer
D) Dermis replaced by CT
A

A) LS
B) LP
C) LP
D) LS

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13
Q

Histo of genital herpes

A

Nuclei have ground glass appearance

Multinucleated giant cells

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14
Q

MC birth defect of male genitalia

A

cryptorchism (undescended testes)

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15
Q

2nd MC birth defect of male genitalia. Explain what it is.

A

hypospadias (urethral opening on ventral aspect of penis)

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16
Q

What is the birth defect of male genitalia where urethral meatus opens on dorsum of penis?
Common or rare?

A

epispadias. rare

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17
Q

What is the condition where the foreskin cannot be fully retracted over the glans of the penis? Risk?

A

Phimosis. Penile CA

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18
Q

Condition where the foreskin becomes trapped behind the glans. Risk?

A

Paraphimosis. Penile CA

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19
Q

Varicocele, Hydrocele, or Torsion?
A) assoc with bell clapper deformity - congenital
B) fluid accumulation (secreted by tunica vaginalis)
C) 85-90% on left side
D) enlargement of vein draining testicles

A

A) Torsion
B) Hydro
C) Varico
D) Varico

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20
Q 
Urethritis: Gonococcal or non-Gonococcal?
A) purulent d/c
B) clear d/c
C) granulated cytoplasmic inclusions
D) chlamydia
A

A) Gono
B) Non-Gono
C) Non-Gono
D) Non-Gono

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21
Q 
% of testicular cancers
A) mixed
B) seminoma
C) embryonal carcinoma
D) teratoma
A

A) 40%
B) 35%
C) 10-20%
D) 5%

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22
Q 
Embryonal or seminoma testicular CA?
A) Alpha fetoprotein elevated
B) Assoc with placental alk phos (PLAP)
C) Elev hCG
D) Present in 90% of mixed tumors
A

A) embryonal
B) seminoma
C) embryonal (sometimes seminoma)
D) embryonal

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23
Q

MC solid malignant tumor in males 20-35 yo

A

Primary testicular tumors

24
Q

BV, Trich, or Candida?
A) fishy odor, high vaginal pH
B) foamy d/c
C) clue cells

A

A) BV and Trich
B) Trich
C) BV

25
Q

BV, Trich, or Candida?
A) itching, burning
B) cottage cheese d/c
C) odor absent, pH low

A

A) Trich, Candida
B) Candida
C) Candida

26
Q 
Chlamydia or Gonorrhea?
A) polymorphic leukocytes
B) friable
C) caused by gram neg intra or extracellular diplococci
D) causes pain on urination in males
A

A) N. gonorrhea
B) Chlamydia
C) N. gonorrhea
D) Chlamydia

27
Q

What are risk factors for cervical CA?

A

early age at first intercourse, multiple partners, male partner w/ previous partners, persistent detection of high risk HPV, presence of CA assoc HPV strains, OCP, tobacco, Hx of genital infx, multiparity

28
Q

What HPV strains are MC associated with cervical CA?

A

16, 18, 31, 45 (mostly 16 and 18)

29
Q

What genetic marker is associated with cervical CA?

A

HLA-B7

30
Q 
What Pap/CIN class?
A) atypia, koilocytosis begins
B) mild dysplasia
C) moderate dysplasia
D) severe dysplasia
E) cancer
A 
A) II
B) III/CIN I
C) III/CIN II
D) III/CIN III
E) V
31
Q

Koilocytosis: CIN I, CIN II, or CIN III?
A) diffuse atypia, loss of normal cell maturation
B) widespread dysregulation of cell cycle controls
C) enlarged nuclei, stain darkly w halo-like appearance
D) upregulation of p16ink4 characterizes high risk HPV

A

A) CIN III
B) CIN II
C) CIN I
D) CIN II

32
Q

Histo of cervical carcinoma in situ

A

loss of maturation of squamous epithelium
high nucleus to cytoplasm ratio
hyperchromatic nuclei

33
Q

Histo of endocervical CA

A

enlarged, prominent round or oval nuclei

irregular chromatin distribution

34
Q

DNA poxvirus that infects skin or mucous membranes. Unlike herpes it does not remain in the body when the skin lesions are gone.

A

Molluscum contagiosum

35
Q

Female genital condition assoc w incr risk of vulvar CA

A

Lichen sclerosis

36
Q

Can syphilis be congenital?

A

Yes, can be vertical transfer

37
Q

Condition with hyperpigmented skin plaques. Lesions of red, white, yellow, or multi-pigmented plaques.

A

VIN

38
Q

More than 90% of cases of VIN are assoc w these strains of HPV

A

16, 18, 31, 45

39
Q

MC site of implantation of ectopic endometrial cells

A

ovaries

40
Q

Ovarian cyst that is formed as a consequence of ectopic endometrial tissue that bleeds within the ovary

A

endometrioma (chocolate cyst)

41
Q

Presence of ectopic endometrial tissue within myometrium

A

adenomyosis

42
Q

Characterized by the presence of micro-abscesses or neutrophils within the endometrial glands

A

acute endometritis

43
Q

Characterized by the presence of plasma cells in the stroma

A

chronic endometritis

44
Q

MC gynecologic CA in US.

A

endometrial CA

45
Q

Most common type of endometrial CA?

A

adenocarcinoma

46
Q

20% of endometrial CA are papillary serous carcinoma. These are assoc with what mutation?

A

p53 mutations

47
Q

Discrete, well-circumscribed benign tumors often round, firm and gray white when sectioned

A

leiomyoma

48
Q

MC type of ovarian tumor

A

serous cystadenoma, benign

49
Q

Psammoma bodies are assoc with

A

ovarian serous cystadenoma

50
Q

tumor with tissue or organ components resembling normal derivatives of more than one germ layer

A

teratoma

51
Q

MC type of ovarian CA (what tissue)

A

epithelial (90%)

52
Q

What is one way to differentiate between syphilis and genital herpes?

A

Lesions of syphilis are painless. Genital herpes very painful.

53
Q

“string of pearls” appearance of cysts

A

PCOS

54
Q

Lots of clear/pale cytoplasm, glycogen. lobular cells, intervening stroma, prominent nuclei and nuclear membranes

A

seminoma testicular CA

55
Q

Crowded pleomrph nuclei, nuc atypia, mitosis common

A

embryonal testicular CA

Path IV Final JT (5 decks)

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