Genetics of Cancer Flashcards
(1) how are cancer cells defined
cancer keep dividing and multiplying ignoring normal signals that tells it to stop growing
(2) how are cancer cells defined
cancer spreads to new areas taking over space usually occupied with other cells
def neoplasm
newly formed tumor
def neoplasia
cells grow abnormally or uncontrolled
is cancer clonal
yes
what are oncogenes?
mutated proto-oncogenes
what are suppressor genes
genes that control cell growth
what are repair genes
genes that detect and repair DNA
what do oncogenes do
promote uncontrolled cell growth
what are proto-oncogenes
normal genes that promote cell growth
3 functions of suppressor genes
slow the cell cycle, repair DNA, initiate apoptosis
what repair happens when a dna base is lost
BER - Base-excision repair
what repair happens when there is a bulky adduct on the dna
Nucleotide-excision repair - NER
