Genetics

Question 1

Autosomal Dominant Inheritance

Answer 1

From fathers and mothers to sons and daughters

Question 2

Autosomal Recessive

Answer 2

Incidence Increases with consanguinity

Question 3

Mitochondrial

Answer 3

Inherited from mothers only

Question 4

X-Linked Recessive

Answer 4

Fathers can’t pass to sons
All daughters obligate carriers
Unaffected mothers pass gene to 50% of sons and 50% of daughters

Question 5

X-Linked Dominant

Answer 5

Affected fathers pass gene to all daughters (affected), and no sons

Affected mothers pass gene to 50% of sons and 50% of daughters (all affected)

Question 6

Pseudo-dominant

Answer 6

Recessive condition in >1 generation by bad luck

Question 7

Silent mutation

Answer 7

base substitution doesn’t affect the amino acid produced by a codon

Question 8

Missense mutation

Answer 8

Changes that affect the amino acid produced by a codon

Question 9

Nonense Mutation

Answer 9

Changes that result in a premature stop codon

Question 10

Frameshift mutation

Answer 10

Alteration of reading frame which may lead to entirely different protein or stop codon