genetics Flashcards
single nucleotide polymorphism (SNP)
diff in DNA sequence at the same site of genome btwn 2 diff people
double muscle cattle
myostatin stops muscle hypertrophy after birth
- single point mutation GCGA ➔ GTGA disrupts myostatin
- no control on muscle hypertrophy ➔ double muscled cattle
selective breeding traits
- growth rate
- food efficiency
- muscle
- marbling ability
- coat color
- disease resistance
genetic probability
actual and expected ratios of genotypes may not match in small populations, but in very large populations, actual ratio may come close to the expected
pedigree
genetic representation of a family tree that shows inheritance of a trait or disease across several generations
- shows relationships between herd members & indicates which individuals have or carry the trait/disease
allele frequencys
proportion of a particular allele present in a population, for a specific locus
- # of copies of an allele divided by the # of copies of all possible alleles at that particular locus in a population
genotype frequency
proportion of a particular genotype in a population, at a specified number of loci
Hardy-Weinberg equation
gives expected genotype frequency
- p2 + 2pq + q2 = 1
- genotypic value is the sum of the effects of each allele for that genotype
- additive gene action: each allele present in an animal contributes to the phenotype in an additive manner
partial dominance
expression of the heterozygote is intermediate to the expressions of homozygous genotypes and more closely resembles the expression of the homozygous dominant genotype.
no dominance (incomplete dominance)
intermediate phenotype (blend)
- exactly midway
overdominance
phenotype is more pronounced in a heterozygote than homozygote, but most closely resembles the expression of the homozygous dominant phenotype
epistasis
multiple genes interact to determine phenotype
- ex: albino color in mice, where two recessive alleles at one locus affect expression all other coat color loci
law of segregation
two copies of a gene (1 maternal + 1 paternal) separate so that each gamete receives only one copy
- mendel’s 1st law
- Each gamete will have one allele at any given locus
law of independent assortment
alleles of different genes assort independently of one another during gamete formation
- genetic recombination (crossing-over)
- mendel’s 2nd law
- allele pairs segregate independently of one another
quantitative traits
- phenotypes show a continuous, numerical expression
- bell curve
- affected by combination of diff genes
- phenotypes cannot be divided into a number of discrete classes only continuous range of measurements
- determined by a large number of genes, each with a small effect
- influenced by environmental factors
- ex: height, weight, intelligence