genes of embryogenesis Flashcards
Sonic hedgehog– produced where?
at base of limb in zone of polarizing activity
sonic hedgehog = involved in pattering along what axis? and dvpmt of what?
Ant-post patterning. Dvpmt of CNS
mutation in Sonic Hedgehog causes?
holoprosencephaly
mutation in which dvpmt gene causes holoprosencephaly?
Sonic hedgehog
which gene = responsible for ant-post patterning/CNS dvpmt?
sonic hedgehog
Wnt-7 gene = produced where?
apical ectodermal ridge (thickened ectoderm at distal end of each dvpng limb)
which gene = necessary for organization along dorsal-ventral access?
Wnt-7
which two genes = found at apical ectodermal ridge?
WNT-7 and FGF gene
which gene stimulates mitosis of underlying mesoderm —> lengthens limbs?
FGF gene
what does FGF gene do?
stimulates mitosis of underlying mesoderm —> lengthens limbs?
homeobox gene involved in segmental org of embryo in which direction?
craniocaudal
Hox mutations lead to…
appendages in wrong directions
