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FIRST AID RANDOM DETAILS > Amyloid > Flashcards

Amyloid Flashcards

1
Q

what type of amyloid is assoc w/ secondary amyloidosis (auto immune diseases, chronic ifxn)

A

AA

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2
Q

AA is assoc w/what diseases?

A

secondary amyloidosis (auto immune diseases (RA, IBD, spondyloarthropathy), chronic ifxn)

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3
Q

clinical manifestation of AA amyloid assoc w/secondary amyloidosis (auto imm. disease/chronic ifxn)

A

deposition in kidney, spleen, liver– most commonly presents as renal insuff/nephrotic syndrome

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4
Q

A-beta amyloid = assoc w/what disease?

A

Alzheimer’s Disease

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5
Q

what type of amyloid = assoc w/Alzheimers?

A

A-beta

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6
Q

what clinical manifestations = assoc w/ A-Beta?

A

dementia (Alz. disease)

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7
Q

AB2M (A beta-2Microglobulin) amyloid = assoc. w/what?

A

long-term dialysis (ie ESRD)

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8
Q

what amyloid = assoc. w/long term dialysis?

A

AB2M (A beta-2Microglobulin)

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9
Q

what clinical manifestations = assoc w/AB2M amyloid from long-term dialysis?

A

deposits in muscles, ligaments, synovium, bone —> arthropathy, carpal tunnel, fractures, MSK probs

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10
Q

what type of amyloid = assoc w/medullary thyroid carcinoma (related to calcitonin)?

A

A Cal

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11
Q

A Cal amyloid = associated w/what disease?

A

medullary thyroid carcinoma (related to calcitonin)

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12
Q

A Cal amyloid from medullary thyroid carcinoma = assoc. w/what clinical conditions?

A

deposition in the tumor, no known clinical consequences

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13
Q

AL or ATTR amyloid are associated w/what type of amyloidosis?

A

primary amyloidosis

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14
Q

primary amyloidosis = assoc w/what types of ammyloid?

A

AL or ATTR

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15
Q

primary AL amyloid = assoc. w/what clinical conditions?

A

light chain deposition (can be due to Multiple myeloma)- affects everything! heart (failure/arrythmia), kidney (nephrotic), hematologic (easy bruising), hepatomeg, neuropathy

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16
Q

primary ATTR amyloid = assoc w/what clinical manifestations?

A

mostly cardiac

17
Q

Amylin = amyloid assoc. w/what disease?

A

T2D

18
Q

T2D = assoc w/which type of amyloid?

A

Amylin

19
Q

Amylin amyloidosis from T2D causes what clinical manifestations?

A

Depo in islet cells of pancreas– unclear clinical consequence

20
Q

what is a heritable type of amyloid?

A

ATTR neurologic/cardiac amyloidosis due to transthyretin (TTR or prealbumin) gene mutation

21
Q

describe age-related (senile) systemic amyloid

A

deposition of normal TTR in myocardium– slower onset of cardiac dysfunc than AL amyloidosis

22
Q

Amyloid-Beta in Alz = cleaved from what prot?

A

APP (amyloid precursor prot)

FIRST AID RANDOM DETAILS (6 decks)

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