General Concepts of Pathophysiology- 3 Flashcards
wound healing stage 1 : _____ phase (immediate to 2-5 day). ____ and ____ occur during this time
hemostasis (vasoconstriction, platelet aggregation, thrombus formation) and inflammation (vasodilation, leukocyte diapedesis and phagocytosis)
Stages of wound healing
1.
2.
3.
- Inflammatory phase
- Proliferative phase
- Remodeling phase
Healing by first intention (primary union):
wound edges are approximated (Brought together)
Healing by second intention (secondary union):
wound edges are not approximated, defect fills in slowly over time
Healing by second intention results in a large tissue defect that must be filled by _____
gradual expansion of granulation tissue
granulation tissue must grow in from ___. and cause increased likely hood of _____
margins; significant scarring and wound contracture
Repair of damaged tissue requires replacement of ______ and ______
parenchymal cells and stromal proteins
Fibrosis= _____
scarring
components of fibrosis: 1. 2. 3. 4.
- fibroblast migration and proliferation
- collagen matrix deposition
- growth of new blood cells (angiogenesis)
- remodeling
the first tissue is granulation tissue: it is new ____tissue from fibroblasts and ____ networks that form at the base of a wound.
connective; capillary
Tissue remodeling is a result of _____
site-specific changes in balance of collagen / matrix synthesis versus degradation by metalloproteinases
metalloproteinases are produced by many tissue cells, and they are _____ by tissue inhibitors of metalloproteinase produced by many of the same tissues
rapidly inactivated
Modifiers of wound healing (8)
nutrition, metabolic status, circulatory status, glucocorticoids, infection, foreign bodies, size, location, type of wound, early stress on wound
Tensile strength of wound increases slowly to _____ by ____ months (its new maximum strength)
80% by 3-13 months
increased tensile strength is related to net ______ and ____ cross linking
collagen; collagen
