General Anatomy and Biology Flashcards
What is anatomy?
The structure of organisms
What is physiology?
The functions and activities of organisms
Describe the structure of the human body from atom to human being
- Atoms come together to form…
- Molecules, which come together to form an…
- Organelle, which comes together with other organelles to form a…
- Cell, a group of cells working together come together to form a…
- Tissue, tissues working together and to perform a similar function form an…
- Organ, a group of organs working together to perform a specific function form an…
- Organ system, a group of organ systems working together to perform different duties to maintain life make a…
- Human being
What is a cell?
A cell is the basic structural and functional unit of all organisms
What are the three main parts of the cell?
- The cell membrane
- Cytoplasm
- Nucleus
What is the cytosol?
The fluid that stores organelles and allows transport of molecules
What is cytoplasm?
Cytoplasm is the cells organelles + cytosol
What is the double membrane that surrounds the nucleus?
The nuclear envelope
What is the endomembrane system (EMS)?
The endomembrane system is responsible for packaging, modifying and transporting proteins and lipids
What do nuclear pores do?
Nuclear pores allow transport of proteins and molecules in and out of the cell
What does the nucleus do?
It is the site of DNA replication and it holds the cell’s DNA.
What are nuclesomes?
Nucleosomes are DNA wrapped around histones
What is a chromatin?
A chromatin is a group of eight histones that have DNA wrapped around them. It is essentially condensed nucleosomes that gather together and form chromatin.
What shape are chromosomes when the cell is not replicating?
They are straight and not x-shaped
Where are ribosomes assembled.
The nucleolus has RNA which is responsible for protein synthesis
What molecules do ribosomes synthesize?
They synthesize proteins, their location determines whether proteins leave or stay in the cell.
How many membranes do mitochondria have?
Mitochondria have a double membrane like the nucleus
Is the mitochondria part of the EMS?
The mitochondria is not part of the EMS
What does the mitochondria do?
It is the site of ATP synthesis from food
What is the cristae?
The cristae is the inner curled layer of the mitochondrial membrane
What is stored in the cristae?
Proteins for ATP synthesis
What is the fluid in the mitochondria called?
The mitochondrial matrix
What is stored in the fluid in the mitochondria?
Ribosomes and mitochondrial DNA
How do humans inherit mitochondrial DNA?
They inherit it from their mothers
What is the endosymbiont theory?
The endosymbiont theory says that mitochondria are alien to animals and may have developed from prokaryotic cells hence the presence of DNA in them
What is DNA outside the nucleus called?
Extrachromosomal DNA
What are the two types of endoplasmic reticulum?
Rough and smooth
What is the function of the endoplasmic reticulum?
To synthesize molecules that go to the other parts of the cell
Is the Endoplasmic Reticulum part of the EMS?
Yes
How many membranes does the ER have?
One
Why is the rough endoplasmic reticulum called rough?
It has ribosomes
What is the function of the rough endoplasmic reticulum?
The rough endoplasmic reticulum synthesizes and modifies proteins for transport to other parts of the cell.
Why is the smooth endoplasmic reticulum called smooth?
It has no ribosomes
What is the function of the smooth endoplasmic reticulum?
The function of the smooth endoplasmic reticulum is lipid synthesis
How does the smooth endoplasmic reticulum help with toxins?
It helps with detoxification of cells
What are the transport vesicles?
The transport vesicles transport molecules to parts of the cell
Are transport vesicles part of the EMS?
Yes
What is exocytosis?
Exocytosis is the transporting of materials outside the cell
How many membranes does the golfi apparatus have?
One
What is the cisternae?
The cisternae are flat folds of the Golgi apparatus
What are the two faces of the golgi?
Trans face and the cis face
What is the function of the cis face of the Golgi apparatus?
The cis face of the Golgi accepts transport vesicles from the rough endoplasmic reticulum
What is the function of the trans face of the Golgi apparatus?
The trans face of the Golgi apparatus sorts and transports modified proteins and lipids to other parts of the cell or to be excreted
What does the center of the Golgi do?
The center of the Golgi modifies molecules by adding extra chemicals to them
How does the Golgi ensure that modified molecules end up in the right place?
By encoding vesicles with signaling sequences to determine where the final product should be transported
What is responsible for sorting vesicular transport in the cell?
COP I, COP II and Clathrin protein coated complex vesicles
What direction do COP I coated vesicles head in?
Retrograde, from the cis Golgi to the Rough endoplasmic reticulum
What direction do COP II coated vesicles head in?
Anterograde, from the Rough endoplasmic reticulum to the cis Golgi
What direction do the clathrin coated vesicles head in?
Trans Golgi to lysosomes and receptor mediated endocytosis which brings new stuff in the cell
What is the function of both lysosomes and peroxisomes?
Digesting matter within the cell
Are lysosomes part of the EMS?
Yes, they are membrane bound
What type of enzymes do lysosomes have?
They have hydrolitic enzymes
What is the function of lysosomes?
Lysosomes break down cellular matter and molecules using hydrolitic enzymes
What is the process of autophagy?
Autophagy is the digestion of a cells matter using lysosomes
What is the process of phagocytosis?
Phagocytosis is the breakdown of matter from outside the cell using lysosomes
What is the process of autolysis?
Autolysis is the process of cell death that occurs when lysosomes release hydrolitic enzymes into the cell
When does autolysis occur?
It occurs when a cell is injured or diseased
Are peroxisomes part of the EMS?
No, despite being membrane bound
Through what process do peroxisomes break down molecules?
Oxidation
What material do peroxisomes form?
They form hydrogen peroxide by stealing hydrogen from substrates using enzymes
What material do peroxisomes breakdown with enzymes?
Hydrogen peroxide broken down into water and oxygen
What part do peroxisomes play in detoxification?
They neutralize toxins in the cell
What substance do peroxisomes metabolize?
They metabolize fatty acids
What happens to the substance that is metabolized by peroxisomes?
The metabolized fatty acids are used in energy production for the cell
Which cell components manufacture some lysosomes?
Cell membrane and Golgi apparatus
What is another name for the cell membrane?
Plasma membrane
What is the inside of the cell called?
Intracellular membrane
What is the outside of the cell called?
The extracellular membrane
What does the “fluid” of the “fluid membrane mosaic mode” mean?
The contents is the cell membrane are always moving
What does the “mosaic” of the “fluid mosaic model” mean?
It means the cell membrane has lipids carbs and proteins or more than one substance
Describe the phospholipid bilayer of the cell membrane
Hydrophilic head
Hydrophobic tail
What function does cholesterol play in the cell membrane?
The cholesterol stabilizes the phospholipids in the cell membrane
How does cholesterol regulate membrane fluidity at different temperatures ?
By making cell membrane more fluid at low temps and keeping it from becoming more fluid at high temps
How does cholesterol prevent harmful materials from accumulating in the cell?
It fills in the gaps of the phospholipid bilayer preventing harmful substances from entering
What is the third type of fatty cell in the membrane?
Sphingolipids
What is a caveat about the use and number of sphingolipids in the cell?
Their use and number depends on cell type
What is the type of lipids found in the fluid membrane?
Lipid rafts
What material are lipid rafts high in?
They are high in both cholesterol and sphingolipids
How does the high presence of cholesterol and sphingolipids affect the speed of lipid rafts?
It slows down their movement
What part does the speed of lipid rafts play in protein attachment?
They aid in protein attachment and cell signaling
What are flippases?
Flippases are enzymes that use ATP to change the direction of phospholipids from one end of the plasma membrane to the other
What are transmembrane proteins?
They are cell membrane proteins that occur in the entire cell membrane
What types of transmembranes proteins are available?
Channel
Transporters
Receptors
What do transmembrane proteins do?
They connect the cytosol to the extracellular environment
What are embedded proteins?
Embedded proteins are proteins found in both the cell membrane and intracellular membrane
What are both transmembrane and embedded proteins referred to as?
Integral proteins because they are built into the cell membrane
What is another name for peripheral proteins?
Membrane associated proteins
Describe the location of the peripheral proteins
Peripheral proteins are not fully integrated into the inner cell membrane or free flowing in the cytoplasm they are bound the the phospholipid bilayer or trans membrane proteins
Where are carbohydrates found?
Extracellular matrix