gene therapy

Question 1

germ line gene therapy

Answer 1

when a functional gene is added to gametes resulting in all somatic cells of org inheriting the functional gene

Question 2

somatic cell gene therapy

Answer 2

func gene added to somatic cells which cx pass func gene to offspring

Question 3

give a method other than using a virus of putting a func allele into the correct body cells, inc vector and method of delivery

Answer 3

use liposomes as vectors

deliver through inhaler to be taken up by lungs

Question 4

explain some of the problems ass w/somatic cell gene therapy

Answer 4

func gene into right cells
ensure vector allele inserted into dx trigger an immune response
prov correct regulatory mech elements 4 turning allele on and off at correct times

Question 5

why might adult stem cells be more useful to gene therapy that embryonic stem cells

Answer 5

gen id to indiv
readily available/ might not have kept umbilical cord
ethical issues of embryonic stem cells

Question 6

describe diffs bw somatic cell and germ line cell gene therapy

Answer 6

somatic cell-

germ line-

Question 7

describe diffs bw somatic cell and germ line cell gene therapy

Answer 7

somatic cell- func gen not passed on, body cells

germ line- func gene passed on, gametes

Question 8

how is somatic gene therapy used to treat SCID

Answer 8

func gene inserted into viral vector
virus taken up by cells from bone marrow
cells placed back into bone m, where func gene rep faulty allele