Gen Med Flashcards
Most common cause of hypothyroid
Hashimoto
HPT axis
- Hypothalamus secretes TRH
- TRH stimulates ant pit to release TSH
TSH acts on thyroid to release T3/T4
- TRH stimulates ant pit to release TSH
Investigation of primary hypothyroid
High TSH, low T4
Ix of 2ndary hypothyroid
Low TSH and T4
Ix of subclinical hypothyroidism
High TSH, normal T4
Ix of poor thyroxine compllaiance
High TSH, normal T4 - Take thyroxine on day of appt but TSH lags behind and reveals poor compliance
Ix of hashimoto
• Anti-TPO (thyroid peroxidase) antibody
S&S of hypothyroid
• Systemic: ○ Weight gian ○ Lethargy ○ Cold intolerance • Skin: ○ Dry ○ Non pittine oedema ○ Dry coarse hair GI - constipation
Tx of hypothyroid
Levothyroxine
Tx of hyperthyroid
• Propanolol - to control symptoms
• Radioiodine tx
• Carbimazole:
○ Prevents iodinisation of thyroglobulin
ADR of carbimazole
agranulocytosis
S&S of hyperthyroid
• Systemic: ○ Weight loss ○ Restlessness ○ Heat intolerance • Cardiac: ○ Palpitations • Skin - Increased sweating, clubbing • GI - diarrhoea • Neuro - anxiety, tremor
Ix of graves
TSH receptor antibodies
Precipitating factors of DKA
• Infection
• Missed insulin doses
MI
S&S off DKA
• Abdo pain
• Polyuria, polydipsia, dehydration
• Deep hyperventilation - Kussmaul resp
Pear drop smelling breath
Ix of DKA
• Glucose >11
• pH <7.3
• Bicarb <15mmol
Ketones >3mmol or urine ketones ++
Tx of DKA
• Saline fluids
• Insulin IV infusion
Correct hypokalaemia (due to insulin)
Ix of hyperosmolar hyperglycemic state
• Dehydration • Osmolality >320mOsmol/kg • >30mmol BM • pH >7.3 Bicarb >15mmol
S&S of hyperosmolar hyperglycemic state
• Focal CNS signs - tremors, motor or sensory impaired
• DIC
Leg ischemia
Tx of Hyperosmolar hyperglycemic state
• LMWH
• Saline fluids
• Replace potassium
ONLY USE INSULIN IF BM NOT FALLING WITH ABOVE
S&S of hypoglyc
• Autonomic: ○ Sweating ○ Anxiety ○ Hunger ○ Tremor ○ Palpitations ○ Dizziness • Neuro: ○ Confusion ○ Aggression ○ Drowsiness ○ Visual trouble Seizures
Tx of hypoglyc
Tx:
1. Conscious - 250ml of lucozade, 3 glucose tablets, glucogel 2. IV glucose 200 ml of 10% solution in 50 ml aliquots 3. Repeat glucose testing every 10 mins until stable 4. Review reasons for hypoglyc
Ix of gestational diabetes
• Urine dipstick - Glycosuria
• Glucose tolerance test:
○ Fasting >5.6mmol
2 hr glucose >7.8mmol
What proportion of women with gestational diabetes will develop diabetes?
50% in 10 years
Tx of gestational diabetes
• Managed with insulin
• Perform glucose tolerance test post delivery
Advice on reducing risk of developing T2DM
RFs on gestational diabetes
• BMI >30
• Previous gestational diabetes
• FHx of diabetes
Middle eastern, black, south asian
Patho of diabetic retinopathy
• Increase retinal blood flow
• Therefore, Abnormal metabolism and damage to retinal vessel walls
Increase vascular permeability
Classification of diabetic retinopathy
Background - microaneurysms, blot hemorrhages (3 or less), hard exudates
Pre-proliferative - Cotton wool spots, 3+ blot hemorrhages, cluster hemorrhages
Proliferative - Fibrous tissue anterior to retinal disc, retinal neovascularisation
Tx of diabetic retinopathy
Laser photocoagulation
Tx of hyperlipidaemia - primary and secondary prevention
• Primary prevention - atorvastatin 20 Secondary prevention (known IHD or CVD or PAD) - atorvastatin 80
CVD screening tool + when to offer statin
• QRISK2 CVD risk assessment
Statin offered if QRISK2 10 yr risk of 10+%
Ix of hyperlipidaemia
Full lipid profile - HDL and total most important
Secondary causes of hyperllipidaemia
• DM
• Obesity
• Alcohol
Familial hypercholesterolemia
S&S of cushings
moon face, buffalo hump, CUSHINGOID
Ix of cushings
• Dexamethasone suppression test:
○ Cortisol suppressed - Pituitary source
○ Cortisol not suppressed - Adrenal or ectopic source
• Biochemistry - hypokalaemia with HTN, metabolic alkalosis
Impaired glucose tolerance
ACTH dependent causes of cushings
• Cushings disease - pituitary adenoma secreting ACTH
Ectopic ACTH production - e.g. small cell lung cancer
ACTh independent causes of cushings
steroids, adrenal neoplasia
State HPA axis of cortisol
CRH from hypothalamus to ACTH from ant pit to Cortisol from adrenal
Patho of addisons
• Autoimmune destruction of adrenal glands
S&S of addisons
• Lethargy, weakness, weight loss
• Hyperpigmentation, vitiligo, hypotension
Crisis - collapse, shock, pyrexia
Ix of addisons
• ACTH stimulation test (synacthen):
○ No increase in cortisol - Addisons diagnosed
Biochemistry - hyperkalaemia, hyponatraemia, hypoglycaemia, metabolic acidosis
Tx of addisosn
• Hydrocortisone and fludrocortisone
Illness - double hydrocortisone
What do you do to steroids in illness?
double
Causes of endocrine HTN
acromegaly, phaeochromocytoma, conns
What is pheochromocytoma patho and S&S
• Tumour of adrenal gland • Excess adrenaline production --> vasoconstriction • S&S - Sympathetic: ○ Pallor ○ Palpitations ○ Tachy ○ Anxiety Headaches
What is conns and ix
• Excess aldosterone
• Few symptoms
Ix - low serum renin, high aldosterone
What cancers are MEN type 1, 2a, and 2b associated with?
MEN 1 - 3Ps - Pancreas, Pituitary, Parathyroid
MEN 2a - 2 Ps - Parathyroid, pheochromocytoma
MEN 2b - 1P - Pheochromocytoma
S&S of primary hyperPTHism
abdo pain (moans, stones, groans, psychiatric overtones), HTN
Ix of primary hyperPTHism
○ PTH - High
○ Ca - High
Phos - Low
Cause of primary hyperPTHism and tx
• Cause - adenoma of PT gland (MEN 1 and 2a)
Tx - surgery
S&S of secondary hyperPTHism and ix
• S&S - bone disease eg osteitis fibrosa cystica • Ix: ○ PTH - high ○ Ca - Normal or low ○ Phos - High Vit D - low