Gastrointestinal Flashcards
What disease has an apple core x-ray?
Cancer
What disease has a corkscrew x-ray?
Esophageal spasm
What disease has a stacked coin x-ray?
Intussusception
What disease has a thumbprint x-ray?
Toxic megacolon
What disease has an abrupt cutoff x-ray?
Volvulus
What disease has a barium clumping x-ray?
Celiac sprue
What disease has a bird’s beak x-ray?
Achalasia
What disease has a string sign x-ray?
Pyloric stenosis
Chron’s disease
What diseases have solid dysphagia?
Schatzki’s rings
Stricture
Cancer
What diseases have solid and liquid dysphagia?
Esophageal spasm
Scleroderma (systemic sclerosis)
Achalasia
What is barret’s esophagus?
Metaplasia
Increase risk of adenocarcinoma
What are esophageal varices?
Vomit blood everywhere
Portal HTN
What is mallory-weiss?
Tear LES mucosa
Chronic vomiters
What is boerhaave’s syndrome?
Esophageal wall rupture *tear all layers of esophagus *left-sided pneumo *abdominal pain *pleural effusion *vomiting *retrosternal pain Retrosternal pain
What is achalasia?
Lost lower esophageal sphincter auerbach’s plexus
Bird’s beak
Chaga’s
What is hirschsprung’s disease?
This disease cause obstruction in colon
*Lost rectum auerbach’s plexus
What is zenker’s diverticulum?
Diverticulum of the mucosa of the pharynx
False diverticulum (involve all layers of structure)
*cough undigested food
*halitosis
What is traction diverticulum?
Esophageal diverticulum
True diverticulum (only involve submucosa and mucosa)
*eat big bolus
What is plummer-vinson syndrome?
- Esophageal webs (dysphagia-difficulty in swallow and odynophagia- painful swallow)
- Iron deficiency (anemia)
- Glossitis
What is schatzki rings?
Esophageal webs in lower esophagus (cause dysphagia)
What is TE fistula?
Tracheoesophageal fistula
Fistula between esophagus and trachea
*Choke w/each feeding
What is an esophageal atresia w/ TE fistula?
Vomit w/ first feeding
Huge gastric bubble
What is duodenal atresia?
Bilious vomiting w/ first feed
Double bubble
All infants with Down’s syndrome have duodenal atresia
What is pyloric stenosis?
Projectil vomiting (3-4 week old) Right upper quadrant olive mass
How does choanal atresia present?
Turns blue with feeding
How is the tetralogy of fallot presentation different?
Turns blue with crying
What makes scleroderma unique?
Decrease LES pressure
What makes esophageal spasms unique?
Increase peristalsis
What makes achalasia unique?
Decrease peristalsis and increase LES pressure
What disease has a RUQ olive mass?
Pyloric stenosis
What disease has a RLQ sausage mass?
Intussusception
What is a bezoar?
Mass of hair or vegetables
Cause antrum obstruction
What is gastritis type A?
Upper GI bleed
Anti-parietal cell Ab
What is gastritis type B?
Upper GI bleed
Spicy foods
H.pylori
What is duodenal ulcer?
Too much acid: pain after meal/at night
Type O blood
H.pylori
Pain relieved by eating
What is a gastric ulcer?
Broken mucus layer: pain during meal
Type A blood
Caused or worsened with NSAID’s (aspirin, ibuprofen, diclofenac and naproxen)
What is hiatal hernia?
Herniation of upper part of stomach into thorax
What is a sliding hiatal hernia?
Most common hernia
Type I hernia
Upward dislocation of cardia
Sucks acid into thorax
What is rolling hiatal hernia?
Fundus stick through hole in diaphragm
Type II hernia
Upward dislocation of gastric fundus
What is menetrier’s disease?
Protein loss
Stomach rugal folds
Associated w/excessive secretion of TGF-alpha
What defines constipation?
Common cause of painful defecation
<3 bowel movement per week
Fecal impaction which can progress to bowel obstruction
What defines diarrhea?
Condition of having 3 or more loose or liquid stools per day
Most common cause is gastroenteritis
>200g per day
What is osmotic diarrhea?
Watery
What is secretory diarrhea?
Laxative use
What is inflammatory diarrhea?
Blood
Pus
What is celiac sprue?
Disorder of small intestine
Jejunum
Wheat allergy
Villous atrophy
What is tropical sprue?
Ileum celiac sprue
What is mesenteric ischemia?
Inflammation and injury of small intestine Result from inadequate blood supply Pain out of proportion to exam Cause: (decrease blood flow) *low blood pressure *constriction of blood vessels *blood clot
What bugs cause bloody diarrhea?
“CASES”:
- campylobacter
- amoeba (E.histolytica)
- shigella
- e-coli
- salmonella
What is the difference b/w primary biliary cirrhosis and primary sclerosing cholangitis?
*Primary biliary cirrhosis= anti-mitochondrial Ab, bile ductules
destroyed, xanthelasma (yellowish deposit of
fat in the skin)
*Primary sclerosing cholangitis= p-anca Ab (Perinuclear Anti-
Neutrophil Cytoplasmic Antibodies), bile duct
inflammation, beading, onion skinning, assoc.
w/ UC
What is ascending cholangitis?
Common duct stone gets infected
What are the signs of alcoholic cirrhosis?
Spider angioma
Palmar erythema
Gynecomastia
Dupuytren’s contraction= fingers bend towards the palm and cannot
be fully extended (straightened)
What is hepatorenal syndrome?
Is the development of renal failure in patients with advanced chronic liver disease
What is cholangitis?
Inflammation of bile duct
Charcot’s triad= three common findings in cholangitis: abdominal pain,
jaundice and fever
What is cholecystitis?
Inflammation of gallbladder
Murphy’s sign
What is cholelithiasis?
Formation of gallstones
Right upper quadrant colic
What is choledocholithiasis?
Gallstone obstructs bile duct
What is cholestasis?
Obstruction of bile duct Cause: *pruritus *elevation of alkaline phosphatase *jaundice
What is conjugated bilirubin?
Water soluble “direct”
What is unconjugated bilirubin?
Fat soluble “Indirect”
What is the most common type of gallstone?
Cholesterol (can’t see on x-ray)
What type of gallstones can be seen on x-ray?
Ca-bilirubinate
What is a xanthoma?
Cholesterol buildup (elbow and achilles)
What is xanthelasma?
Triglyceride buildup (under eye)
HDL cholesterol?
Good cholesterol
LDL cholesterol?
Bad cholesterol
What does high cholesterol cause?
Atherosclerosis
What do high triglycerides cause?
Pancreatitis
What is type 1 hyperlipidemia?
Bad liver LL (lipoprotein lipase)
What is type 2a hyperlipidemia?
Bad LDL or B-100 receptors
What is type 2b hyperlipidemia?
Less LDL/VLDL receptors
What is type 3 hyperlipidemia?
Bad Apo E (IDL/VLDL)
What is type 4 hyperlipidemia?
Bad adipose LL (VLDL only)
What is type 5 hyperlipidemia?
Bad C2 (VLDL/CM) Because C2 stimulates LL (lipoprotein lipase)
What is Crigler-Najjar syndrome?
Is a disorder affecting metabolism of bilirubin
Unconjugated bilirubin
Usually in infants
What is Gilbert’s syndrome?
Is a genetic liver disorder Glucuronyl transferase is saturated Cause: *increase unconjugated bilirubin in bloodstream *jaundice
What is Rotor’s syndrome?
Is a bilirubin disorder
Bad bilirubin storage-conjugated bilirubin
What is Dubin-Johnson syndrome?
Is a disorder that causes increase of conjugated bilirubin
Bad bilirubin excretion-black liver
What is Cullen’s sign?
Is a superficial edema and bruising around umbilicus
Bleed around umbilicus-hemorrhagic pancreatitis
What is Turner’s sign?
Is a bruising of the flanks (blue discoloration)
Bleed into flank-hemorrhagic pancreatitis
What test are used for following pancreatitis?
- Amylase- sensitive, breaks down carbs
* Lipase- specific, breaks down TGs
What does Ranson’s criteria tell you?
Poor prognosis for pancreatitis ptes
What is Ranson’s Criteria at presentation?
“WAGLA”:
- WBC: > 16K/uL (infection)
- Age: > 55 (usually multiple illnesses)
- Glucose: > 200 mg/dL (islet cells are fried)
- LDH: > 350 IU/L (cell death)
- AST: > 250 IU/L (cell death)
What is Ranson’s Criteria at 48 hrs?
“BuCH was a SOB”:
- BUN: > 5mg/dL (decrease renal blood flow)
- Ca: < 8mg/dL (saponification)
- Hct: drops > 10% (bleed into pancreas)
- Sequester: > 6L fluid= > 3rd spacing
- pO2: < 60mm Hg (fluid/protein leak-ARDS)
- Base deficit: > 4 mEq/L (diarrhea-pancreatic enzymes are dead)
What is carcinoid syndrome?
Diarrhea
Flushing
Wheezing
What produces currant jelly sputum?
Klebsiella
What produces currant jelly stool?
Intussusception
Part of intestine invaginated another section of intestine
What is gardener’s syndrome?
Familial polyposis w/ bone tumors
What is turcot’s syndrome?
Familial polyposis w/ brain tumors
What is familial polyposis?
100% risk of colon cancer
APC defect
Annual colonoscopy at 5yrs
What is peutz-jegher syndrome?
Hyperpigmented mucosa
Dark gums/vagina
What is crohn’s disease?
- IBD (inflammatory bowel disease) w/ cobblestones, melena, creeping fat, fistulas
- Autoimmune disorder
- Most often involve lower end of small intestine and the beginning of large intestine
What is ulcerative colitis?
*IBD (inflammatory bowel disease) w/ pseudopolyps, hematochezia, lead pipe colon, toxic megacolon
What is intussusception?
Currant jelly stool
Stacked coin enema
Sx. come and go
How does diverticulosis present?
Bleeds
How does diverticulitis present?
Hurts
How does spastic colon present?
Intermittent severe cramps
How does IBS (inflammatory bowel syndrome) present?
Alternating diarrhea
Constipation
How do external hemorrhoids present?
Pain
How do internal hemorrhoids present?
No pain
What is pseudomembranous colitis?
Overgrowth of C.difficile due to normal flora being killed off
Usually by clindamycin use
What is whipple’s disease?
T.whippleii destroy GI tract
Spread causing malabsorption
Arthralgia (joint pain)
What color is an upper GI bleed?
Black
What color is a lower GI bleed?
Red
What adds color to stool?
Bilirubin
What is the default color of stool?
Clay-colored
What is the default color of urine?
Tea-colored