Gastroenterology by Dr Cintia Flashcards
Diseases of the Small and Large Intestines
Crohn Dx CLINICAL FEATURES
- Pain is more common, affects all colon except for rectum, skip lesions, transmural inflammation, causes fistulas, fissures, noncaseating granulomas, perianal disease.
Crohn Dx FIRST INVESTIGATION
-Stool sample faecal calprotectin (Neutrophil derived biomarker)
-CXR, AXR to see complications of peritonitis or toxic megacolon.
Crohn Dx BEST INVESTIGATION
- Biopsy (Cobblestone sign)
- MRI for perianal dx in Crohn.
Crohn Dx TREATMENT
1.Mild Crohn: Budesonide enteric- coated.
2.Diffuse Crohn: Oral Prednisolone.
3.Methotrexate
4.Azathioprine - Infliximab good for Crohn w/ perianal fistula
Ulcerative Colitis CLINICAL FEATURES
- Bleeding is more common, only affects the mucosa, but all the colon with rectal involvement, loss of haustra, crypt abscesses and ulcers, can cause toxic megacolon, perforation, Assoc w Primary sclerosing cholangitis
Ulcerative Colitis BEST INVESTIGATION
- Biopsy
Ulcerative Colitis TREATMENT
- Mesalazine/Sulfasalazine (Rectal+Oral preparation)
- Add Steroids (Budesonide, hydrocortisone, prednisolone rectally.
- Add Steroids orally (Prednisolone) Methotrexate and sulfasalazine cause oligospermia. But sulfasalazine is safe
to use in pregnancy and methotrexate not
syndrome diaphragmatic hernias
diaphragmatic hernia: Acquired
Congenital Malabsorption
Coeliac disease
Lactose intolerance
Diseases of the liver
Liver Function Test
Jaundice
drug-induced liver injury: Khat herbal leaves
Fatty liver (hepatic steatosis) Non-alcoholic fatty liver disease
Non-alcoholic steatohepatitis
Alcoholic hepatitis CLINICAL FEATURES
- Marked neutrophilia, fever, hepatic pain, tenderness, encephalopathy
Alcoholic hepatitis FIRST INVESTIGATION
- Inc AST>ALT, GGT
Alcoholic hepatitis TREATMENT
If encephalopathy->Prednisolone.
If CI (untreated inf)-> Oxpentifylline (CI in allergy to caffeine or theophylline)
alcoholic liver disease
Autoimmune hepatitis CLINICAL FEATURES
- Cx by infliximab, nitrofurantoin, minocycline
Autoimmune hepatitis BEST INVESTIGATION
Abs:
- ANA (cheaper)
- SMA (Smooth muscle ab) - anti-LKM1 (anti liver kidney microsomes)-assoc w/poor response to tx
Autoimmune hepatitis TREATMENT
Prednisolone + Azathioprine
Haemochromatosis CLINICAL FEATURES
AR. Multiple symptoms.
Accumulate in pituitary (Libido, impotence with low FSH and LH), skin (dark skin), joint
(Polyarthritis), Pancreas (DM), Liver (Chronic hepatitis).
- MC Heart manifestation: CHF
- MCC death: Cirrhosis
Haemochromatosis FIRST INVESTIGATION
- Ion studies- Transferrin saturation>70% (Check transferrin and ferritin e/2y)
Haemochromatosis BEST INVESTIGATION
- HFE gene (C282Y gene- 80-90% pts in Oz are homozygous for this mutation). If Hets pts will not develop symptoms.
Haemochromatosis TREATMENT
- Serial venesection until ferritin is <50ugs. Maintenance venesection 3x/year to keep ferritin<100
Primary Biliary Cirrhosis FIRST INVESTIGATION
-AMA Abs (Antimitochondrial)
Primary Biliary Cirrhosis BEST INVESTIGATION
Biopsy. - Transient elastography to stage severity of dx
Primary Biliary Cirrhosis TREATMENT
Ursodeoxycholic acid for pruritus, LFTs and survival.
Wilson’s Dx CLINICAL FEATURES
AR. Confusion, dysarthria, wide based gate, acute change of personality + cirrhosis - Kayser Fleischer rings
Primary Sclerosing Cholangitis CLINICAL FEATURES
-Assoc w CU.
- stricturing in intra and extrahepatic bile ducts
Wilson’s Dx FIRST INVESTIGATION
- Serum Ceruloplasmin (low) and high 24 hour urinary copper excretion 2. Slip lamp examination (Kayser Fleisher rings)
Hepatitis B CLINICAL FEATURES
-30% likely to pass it if needle injury. Compared to 3% in HCV and 0.03% in HIV.
- Sex is MCC of transmission.
- If HBsAg>6 months: Chronic Hep B
Hepatitis B FIRST INVESTIGATION
-HBsAg: aCute, Chronic, Carrier.
-Anti-HbsAb: cleAred, vAccination.
-Anti-HBcIgM: Acute hep
-Anti-HBcIgG: Chronic, Carrier, Cleared
-HBeAg. Acute&Chronic
Hepatitis B TREATMENT
Chronic:
-Interferon weekly injs for 48w. Not in decompensated liver dx-Do Child Pugh Score)
-Entacavir, tenofovir: Once daily lifelong tx.
Hepatitis C CLINICAL FEATURES
-#1 cx: needle sharing.
-No vaccine available.
-Chronic (>6m).
-10-30% of pts develop Cirrhosis in 20yrs. Compared to HepB that goes to cirrhosis faster
Primary Sclerosing Cholangitis FIRST INVESTIGATION
- US/P-ANCA
Primary Sclerosing Cholangitis TREATMENT
Ursodeoxycholic acid also reduce risk of CRC.
Hepatitis C BEST INVESTIGATION
Liver biopsy looking for cirrhosis
Primary Sclerosing Cholangitis BEST INVESTIGATION
MRCP
Hepatitis A TREATMENT
- Ig useful if immunocompromised and <12months babies. - Vaccine
Primary Biliary Cirrhosis CLINICAL FEATURES
- Pruritus, fatigue, cholestasis in biochemistry
Hepatitis A CLINICAL FEATURES
-Not chronic, travel Hx, endemic in Queensland and NT.
-Exclusion for 7 days after appearance of jaundice OR until resolution of symptoms
-NOTIFIABLE Dx
Hepatitis C TREATMENT
-Sofospuvir/Ledipasvir
-Peginterferon but causes BM supression (Do FBC monthly), depression (give it with low dose
SSRI)
-Do SVR12 (means cure).
Undetectable HCV RNA by PCR 12 weeks after end of tx
Hepatitis D CLINICAL FEATURES
Uncommon in Oz. From migrants If infectious is at the same time with HBV: Fulminant hepatitis. If superinifection-> Chronic hepatitis
Hepatitis D TREATMENT
Peginterferon for at least 48 weeks
Hepatitis C FIRST INVESTIGATION
-Anti HCV
-HCV RNA
-Serial ALT (3x in 6m) to see progression
Hepatitis E CLINICAL FEATURES
Dangerous in prEgnancy, oldEr pts, and preExisting liver dx-> acute liver failure
Hepatitis E TREATMENT
Ribavirin
Liver Tumors Simple
Liver cysts Benign: Hepatic Adenoma CLINICAL FEATURES
Young pts with benign tumour linked to OCPs or fertile women. - Pain, spontaneous rupture and haemorrhage are complications (esp in pregnancy).
Liver cysts Benign: Hepatic Adenoma TREATMENT
Resection before pregnancy should be indicated.
Liver cysts Benign: Hemangioma
Malignant - HEPATOMA or hepatocellular carcinoma HCC CLINICAL FEATURES
- Cx: Chronic alcoholism, Hep B C D infection, obesity, DM, smoking
Malignant - HEPATOMA or hepatocellular carcinoma HCC FIRST INVESTIGATION
Surveillance:
-Nodule<10mm: US e/3m
-Nodule>10mm: Contrast CT/MRI.
-Tumour marker: AFP
Malignant - HEPATOMA or hepatocellular carcinoma HCC BEST INVESTIGATION
Biopsy
Malignant - HEPATOMA or hepatocellular carcinoma HCC TREATMENT
Qx resection is not advised
- Sorafenib can prolong survival
Secondary liver cancer (Metastatisis)
Cirrhosis CLINICAL FEATURES
- Low albumin is best indicator of cirrhosis
Cirrhosis FIRST INVESTIGATION
- LFTs, FBE: Thrombocytopaenia, altered IRN, low albumin
- US.
- CT/MRI
Cirrhosis BEST INVESTIGATION
Liver Biopsy
Portal hypertension
Gastro-oesophageal Varices
Ascites
Hepatorenal syndrome (HRS)
Hepatic Encephalopathy TREATMENT
- Lactulose
- Rifaximin
Hepatic Encephalopathy CLINICAL FEATURES
- Changes in personality, sleep, disorientation, flapping tremor, impaired ability to draw 5-point star
Portal vein thrombosis
Spontaneous Bacterial Peritonitis CLINICAL FEATURES
- MCC: E. coli, Klebsiella.
- Ascitic pt that deteriorates with altered mental status, fever, abd pain, inc WBC
- Mechanism: Bacterial translocation from gut to mesenteric lymph node
Spontaneous Bacterial Peritonitis BEST INVESTIGATION
Ascitic fluid culture: WBC>0.5 or neutrophil>0.25 is dx
Spontaneous Bacterial Peritonitis TREATMENT
- Empirical: Ceftriaxone OR Cefotaxime. If allergy to penicillin: cipro OR aztreonam.
- Secondary prophylaxis with Bactrim
Proton pump inhibitors
Globus Hystericus CLINICAL FEATURES
Sensation of something in throat, symptoms of reflux. Nothing on PE
Pharyngeal Pouch CLINICAL FEATURES
> 70yo male, normal neck, regurgitation of undigested food, halitosis, dysphagia
Pharyngeal Pouch BEST INVESTIGATION
- Barium swallow
Pharyngeal Pouch TREATMENT
Stent
Eosinophilic Oesophagitis CLINICAL FEATURES
Hx of atopy, symptoms of GORD
Eosinophilic Oesophagitis FIRST INVESTIGATION
- PPI
Eosinophilic Oesophagitis BEST INVESTIGATION
Endoscopy with biopsy
Eosinophilic Oesophagitis TREATMENT
- PPI for 4-8 weeks
- Fluticasone swallowed for 8w
- Oral prednisolone
Achalasia CLINICAL FEATURES
Dysphagia (intermittent to solids and liquids), posture to aid swallowing, food that sticks, slow eaters.
Achalasia FIRST INVESTIGATION
- Endoscopy. If not available->Barium swallow-Bird’s beak
Achalasia BEST INVESTIGATION
Oesophageal manometry (Increase pressure)
Achalasia TREATMENT
- Young: Endoscopic Pneumatic Dilation (Less invasive) or Laparoscopy Myotomy
-Old: Nifedipine, botulin inj.
Presbyoesophagus CLINICAL FEATURES
Old pts with dysphagia and low amplitude contractions on manometry
Oesophageal Candidiasis CLINICAL FEATURES
In immunocompromised pts
Oesophageal Candidiasis TREATMENT
-Asymptomatic and not immunocompromised-Nystatin for 14 days
- Symptomatic or Immunocompromised: Fluconazole 14-21d
Viral Oesophagitis CLINICAL FEATURES
Cause: HSV, CMV
Viral Oesophagitis BEST INVESTIGATION
Endoscopy w/ biopsy for pathology and PCR
Viral Oesophagitis TREATMENT
Acyclovir IV followed by famciclovir/vala for 10 days
Barrets Oesophagus CLINICAL FEATURES
Metaplasia (From squamous to simple columnar)
Most imp RF for Oesophageal adenocarcinoma
Barrets Oesophagus BEST INVESTIGATION
Endoscopy w/ biopsy
Barrets Oesophagus TREATMENT
- PPI
- Surveillance Metaplasia. Review in 3-5y if <3cm or 2-3y if ≥3cm.
- Dysplasia- Endoscopy e/6m - High grade dysplasia: Refer.
* PPI America recommends 3m in dysplasia
Oesophageal Cancer CLINICAL FEATURES
-Adenocarcinoma (MC in Oz, assoc w/ Barret).
-SCC (MC in world. Assoc w/ SAD).
-Progressive dysphagia first to solids then liquids, hiccoughs, hoarnesess, cough
Oesophageal Cancer BEST INVESTIGATION
- Endoscopy w/ biopsies.
If unavailable->Barium
Oesophageal Cancer TREATMENT
Surgery. CI in lesion>10cms, invasion to tracheobronchial tree and great vessels
Mallory Weiss CLINICAL FEATURES
Haem stable. Asoc w/ alcoholic binge
Mallory Weiss BEST INVESTIGATION
Endoscopy
Mallory Weiss TREATMENT
80-90% stops spontaneously
Complete Oesophageal rupture CLINICAL FEATURES
Chest pain, subcutaneous emphysema, crunching sound w/ heartbeat (Hamman’s sign)
Boerhave’s Sx CLINICAL FEATURES
Haem unstable. Complete transmural tear
Boerhave’s Sx FIRST INVESTIGATION
- X-ray
Boerhave’s Sx BEST INVESTIGATION
- Gastrograffin. Never Barium
Boerhave’s Sx TREATMENT
- Atbs, fluids, Qx.
GORD CLINICAL FEATURES
Belching, odynophagia
GORD FIRST INVESTIGATION
- PPI
GORD BEST INVESTIGATION
> 10y with GORD: Endoscopy to r/o Barrett
GORD TREATMENT
1.LSM weight loss
2.Magnesium/Aluminum hydroxide.
3.H2 blocks
4.PPI (6-8w if severe). SEs: Interstitial nephritis, alabsorption (Iron, Mg, Ca).
5.Qx: Roux-en-Y: BMI>40, or BMI>35 w/ DM, HTN. Comp of Qx: anastomotic leak (perforation)
Upper GI Bleeding CLINICAL FEATURES
-MCC: PUD.
- Tachy, hypotension, sweating
Upper GI Bleeding TREATMENT
- Admission, IV fluids, PPI IV
- Endoscopy to identify bleeding point
- Endoscopic haemostasis, Qx
Hydatid Cyst CLINICAL FEATURES
Farmer, reservoir in dogs and cattle, can happen in liver (jaundice, RUQ pain, vomiting) or lung (SOB, chest pain, cough)
Hydatid Cyst FIRST INVESTIGATION
US
Hydatid Cyst BEST INVESTIGATION
CT
Hydatid Cyst TREATMENT
- Qx w/PAIR technique (Puncture, Aspiration, Inj of hypertonic or ethanol), Reaspiration. - Albendazole for 4w after Qx. - Praziquantel if cysts are spilled during surgery or complicated cysts.
Liver Abscess CLINICAL FEATURES
-MCC: Klebsiella (Risk of Endopthalmitis). In children Staph Aureus. In NA: Melioidosis (Bulkdolheria). In travellers: E. hystolytica
Liver Abscess FIRST INVESTIGATION
US
Liver Abscess BEST INVESTIGATION
CT (Irregular multiple). Blood cultures
Liver Abscess TREATMENT
-<5cm: Close needle drainage - >5cm: Rx guided catheter.
-Empiric Atbs: Gentamicin+Amoxi+Metro for 4-6w. If CI to genta: Ceftriazone or Cefotazime.
-Confirmed Klebsiella: Ceftriazone or cefotaxime.
-If high fever, tender lymphadenopathy, effusion at base of right chest->Amebiasis. Percutaneous CT aspiration+Metro
NASH CLINICAL FEATURES
Increased AST, ALT, GGT.
NASH TREATMENT
- LSM.
- Statins. Metformin for DM risk
Simple liver cysts CLINICAL FEATURES
Asymptomatic, or dull right upper pain, jaundice
Simple liver cysts FIRST INVESTIGATION
US
Simple liver cysts BEST INVESTIGATION
CT
Ascites TREATMENT
- Mild: low salt. If symptomatic use spironolactone, if painful gynaecomastia use amiloride. - Moderate: Spironolactone, if insufficient add furosemide, if tense ascites paracentesis
Refractory: Repeated paracentesis, shunt, liver transplantation
Gastro-oesophageal varices FIRST INVESTIGATION
Dx endoscopy in all pts with cirrhosis looking for varices
Gastro-oesophageal varices TREATMENT
- Propranolol w or without endoscopic variceal band ligation. - Endoscopy e/ 6-12m - Acutely Bleeding:
1.IV line + PPI
2.Blood transfusion.
3.Octreotide to reduce portal pressure
4.Prophylactic Atb with Ceftriaxone OR Cipro IV
H pylori infection CLINICAL FEATURES
RF for gastric cancer.
H pylori infection FIRST INVESTIGATION
- Serology Test
H pylori infection BEST INVESTIGATION
Biopsy urease testing
H pylori infection TREATMENT
- PPI+Amoxi+Clarythro. If penicillin allergy: PPI+Metro+Clarythro. - Post-tx you do Urea breath test 4 weeks after starting tx.
Autoimmune Gastritis CLINICAL FEATURES
Abs against parietal cells and IF. Atrophy of mucosa of stomach
Autoimmune Gastritis BEST INVESTIGATION
Endoscopy w/ biopsy
Autoimmune Gastritis TREATMENT
IM Vitamin B12
Peptic Ulcer Dx CLINICAL FEATURES
-Gastric has more vomiting and weight loss
-Duodenal no vomiting and no weight loss.
-Strictures as comp: If in pylorus (vomiting within 1 hour of meal), duodenal (after 1hr of meal)
Peptic Ulcer Dx FIRST INVESTIGATION
Urea Breath test: To monitor response to tx of H pylori
Peptic Ulcer Dx BEST INVESTIGATION
Endoscopy. Compulsory for pts>55yo w/ chronic dyspepsia to r/o Ca
Peptic Ulcer Dx TREATMENT
- PPI IV
- Injection of adrenaline
Gastric Outlet Obstruction CLINICAL FEATURES
- Pt with vomiting>1hr after eating with undigested food with hx of chronic PUD
Gastric Cancer CLINICAL FEATURES
-MCC: H Pylori infection
-Asymptomatic, later dysphagia, epigastric mass, Virchow’s node (left supraclavicular node), hard irregular hepatomegaly, anaemia
Gastric Cancer BEST INVESTIGATION
Endoscopy+Biopsy
IBS CLINICAL FEATURES
Abd pain assoc w/ change in bowel habit.
IBS FIRST INVESTIGATION
Stool examination w/ fecal calprotectin
IBS TREATMENT
- LSM
- High fibre diet
- Loperamide, TCAs, SSRIs
Meckel Diverticulum CLINICAL FEATURES
- Lower GI bleeding, abd pain
Meckel Diverticulum FIRST INVESTIGATION
- Endoscopy
Meckel Diverticulum BEST INVESTIGATION
- CT
Celiac Dx CLINICAL FEATURES
-Assoc w/ dermatitis
herpetiformis, thyroid dx, DM 1, IgA deficiency, primary biliary cirrhosis, lymphoma of small bowel
-Lethargy, diarrhoea, abd pain, bloating, indigestion, bleeding (Vit K def), steatorrhea
-Skinny arms with flat bum and big belly. Symptoms started by 4-5m when started Cerelac
Celiac Dx FIRST INVESTIGATION
-IgA anti-tissue transglutaminase and anti-deamidated gliadin antibody.
-If pt is already on gluten free diet, give gluten for 4-6w and repeat test
Celiac Dx BEST INVESTIGATION
Duodenal biopsy with villous atrophy and intra epithelial lymphocytosis
Celiac Dx TREATMENT
Avoid BROW (Barley, Rye, Oats, Wheat)
Obscure GI Bleeding CLINICAL FEATURES
Blood persists besides upper and lower endoscopy & Radiologic Ix
Obscure GI Bleeding FIRST INVESTIGATION
- Active: Haem Stable: CT angio Haem Unstable: Interventional
Angiography - Inactive (Occult) Capsule Endoscopy
Carcinoid Tumour CLINICAL FEATURES
Facial flushing, diarrhoea, wheezing, right valvular heart dx
Carcinoid Tumour BEST INVESTIGATION
24hr 5-hydroxyl indole acetic acid, plasma chromogranin A
Carcinoid Tumour TREATMENT
- Octreotide to block serotonin production
- Interferon alpha to reduce growth - Artery embolization to cut blood supply
CRC CLINICAL FEATURES
- Right: 1. Anaemia (Weakness, fatigue). 2nd Palpable mass. - Left: Pain, LB obstruction, altered bowel habits - Sigmoid Ca: Apple core deformity, napkin ring - Rectal Ca: Rectal bleeding, mass in DRE, tenesmus
CRC FIRST INVESTIGATION
For screening see Page 9 of Bleeding.
- Tumour marker CEA
CRC BEST INVESTIGATION
- Colonoscopy
CRC TREATMENT
Surgery (Terminal-terminal anastomoses). If lymphoid Pos ->
Chemo, If lymphoid Neg -> Surveillance (Colonoscopies at 1, 3, 5 years +CEA).
- MC comp post-Qx->Faecal incontinence
Adenomatous Polyps Adenomas CLINICAL FEATURES
Familial Adenomatous Polyposis 100% risk of Cancer
Adenomatous Polyps Adenomas FIRST INVESTIGATION
- FOBT
Adenomatous Polyps Adenomas BEST INVESTIGATION
- Colonoscopy
Adenomatous Polyps Adenomas TREATMENT
Screening w/ Colonoscopy:
- 1-2 polyps & nothing else: 5y
-3-4, high grade dysplasia, villous: 3y
-5-9: Every year
->10: 6 months
HNPCC-Lynch Syndrome CLINICAL FEATURES
AD. Most common hereditary form of Colon Ca. They can also have ovarian, renal, etc.
HNPCC-Lynch Syndrome TREATMENT
Genetic testing
Peutz Jeghers sx CLINICAL FEATURES
Benign polyps (Hamartomas) that can become malignant, freckles on lips, inside mouth, palms, soles.
- Assoc w/ ovarian Ca.
- MC site of Ca: Duodenal Ca.
- Common comp: Intussusception at any age.