Gastro-Viral hepatitis Flashcards
Only human hepatitis virus that is a DNA virus
Hepatitis B
HepaDNAviridae family
Only DNA virus that uses reverse transcriptase enzyme
First detectable HBV marker
HBs Antigen(HBsAg)
Qualitative marker for high infectivity/marker of HBV
HBe Antigen(HBeAg), disappearance is harbinger of clinical improvement and resolution of infection
Quantitative marker for high infectivity/replication of HBV
HBV DNA(correlates with level of liver injury)
First antibody to rise in HBV
Anti-HBc antibody(1-2 weeks after HBsAg)
Positive during window period of HBV
IgM anti-HBc antibody
Protective antibody and the only marker to appear after immunization in HBV
Anti-HBs antibody
Non-percutaneous routes of HBV transmission with greatest impact
Intimate(especially sexual) contact Perinatal transmission (particularly at the time of delivery; not related to breastfeeding)
Most important risk factor for progression to cirrhosis and HCCA in hepatitis B
Level of HBV replication
Vasculitic syndrome associated with HBV infection
Polyarteritis nodosa
Most common symptom in Hepatitis C
Fatigue(jaundice is rare)
Most common risk factor for Hepatitis C
Injection drug use
Most common genotype of hepatitis C worldwide
Genotype 1
Best prognostic indicator in chronic hepatitis C
Liver histology
Defective RNA virus that co-infects with and requires helper function of HBV
Hepatitis D (HDV)
